Biofactors. 2004;22(1-4):271-5. Links
Phase 1 study of multiple biomarkers for metabolism and oxidative
stress after one-week intake of broccoli sprouts.
Murashima M, Watanabe S, Zhuo XG, Uehara M, Kurashige A.
The Department of Applied Bioscience, Tokyo University of Agriculture,
1-1-1, Sakuragaoka Setagaya, Tokyo, 156-8502, Japan. Tel.: +81 3 5477
2453; Fax: +81 3 5477 7222; E-mail: [email hidden].
Little is known about the direct effect of broccoli sprouts on human
health. So we investigated the effect of broccoli sprouts on the
induction of various biochemical oxidative stress markers. Twelve
healthy subjects (6 males and 6 females) consumed fresh broccoli
sprouts (100 g/day) for 1 week for a phase 1 study. Before and after
the treatment, biochemical examination was conducted and natural killer
cell activity, plasma amino acids, plasma PCOOH (phosphatidylcholine
hydroperoxide), the serum coenzyme Q(10), urinary 8-isoprostane, and
urinary 8-OHdG (8-hydroxydeoxyguanosine) were measured. With treatment,
total cholesterol and LDL cholesterol decreased, and HDL cholesterol
increased significantly. Plasma cystine decreased significantly. All
subjects showed reduced PCOOH, 8-isoprostane and 8-OHdG, and increased
CoQ(10)H(2)/CoQ(10) ratio. Only one week intake of broccoli sprouts
improved cholesterol metabolism and decreased oxidative stress markers.
PMID: 15630296 [PubMed - in process]
--------------------------------------------------------------------------------
Who loves ya.
Tom