Hello, We may get many predispositions--may be due to adopting modern lifestyle, polluted environments or modernization etc. In short, we can consider these as, living in unnatural or imbalanced environment....so getting environmental factors in our genes. Due to such imbalances, we may either be increasing our lifespan or shortening it. In short, we may be getting imbalanced lifespan and imbalances in homeostatis. Our body's and nature's system might be trying to balance it. In such thoughts, can we guess that some predispositions be, to increase life span and other to reduce it. Under this consideration, how can we evaluate two most prevailing disorders--diabetes and hypertention. Cancer may be a result/outcome of getting such imbalances but may not be predisposed absolutely. Pls look at following quote and link in this regard:- "Insulin action: Increase of DNA replication and protein synthesis via control of amino acid uptake. http://en.wikipedia.org/wiki/Insulin " Excess the DNA replications, lesser can be the lifespan. Excess the oxidations, lesser can be the lifespan, And vice-versa. Under such thoughts how can you evaulate getting diabetes2 esp. when insulin is deficient or not working? Can it be meant to increase lifespan by reducing DNA replications and oxidations? Can glycation be meant to increase lifespan? These are bit deep, dynamic and serious thoughts, so your deep, logical and dynamic understandings are anticipated. Best wishes.