Whenever i read posts comparing the synapse to the six13 i find it funny that some think the synapse is a comfort bike with relaxed geometry. Sure it's marketed that way but if you take the time to compare the geometry numbers on cannondales website the differences are so nominal that there really is no difference. For example, head tube length. A popular claim is that the synapse has a taller head tube giving it a more relaxed riding position but the difference between the synapse & the six13 is 8mm. That's this much [....], not a very noticable difference in my book and if you think your back is going to be saved by that 8mm, it isn't. Another claim is the six13 being so much stiffer than the synapse. below are some numbers from the german Tour Magazin testing "light framesets", sub 1500g frames & forks (synapse missed the mark by 82g). When you compare the stiffness numbers of the synapse it fits in the list somewhere between the Isaac, the Scott, & the Cube. The synapse test results are below the list.
Manufacturer/Model | Fork | Pts | Head Tube Lateral stiffness | BB stiffness | lateral stiffness of the fork | weight frame+headset(!)/fork | comfort
Canyon Ultimate F10 Limited SL Smolik Motivation Race 71Pts 114Nm/° 131Nm/° 54N/mm 1179g/305g 3
Cérvelo R3 Cérvelo 67Pts 92Nm/° 122Nm/° 47N/mm 975g/376g 2
Storck Scenario CD 1.0 Stiletto Light UMS 63Pts 83Nm/° 106Nm/° 48N/mm 1205g/286g 3
Red Bull X-Lite 8000 Red Bull 60Pts 89Nm/° 103Nm/° 43N/mm 1068g/424g 2
Isaac Sonic LTD. Isaac 58Pts 74Nm/° 93Nm/° 48N/mm 1048g/406g 1
Scott CR1 Team Issue Scott CR1 56Pts 89Nm/° 101Nm/° 42N/mm 1001g/406g 1
Cube Litening GTC "SCR Edition" THM Scapula SP 54Pts 82Nm/° 99Nm/° 37N/mm 1224g/273g 3
Look KG 585 Ultra "Crédit Agricole" Look HSC5 SL 53Pts 67Nm/° 98Nm/° 43N/mm 1168g/327g 2
Time VXRS Ulteam Time Avant Ulteam Safe+ 52Pts 61Nm/° 88Nm/° 47N/mm 1098g/360g 1
Felt F1C Carbon Easton EC90-SLX 50Pts 63Nm/° 94Nm/° 34N/mm 1064g/283g 4
KTM Strada LC Prime KTM LC 49Pts 83Nm/° 92Nm/° 31N/mm 1163g/337g 4
Storck Scenario C 0.9 "10th Anniversary" Stiletto Light 47Pts 66Nm/° 92Nm/° 38N/mm 1181g/292g 2
Poison Speed Easton EC90 SLX 39Pts 48Nm/° 85Nm/° 33N/mm 1186g/282g 4
Santana Stylus Easton EC90 SLX 39Pts 59Nm/° 72Nm/° 33N/mm 1213g/287g 4
Cannondale Synapse Carbon Carbon S.A.V.E. 64Pts 71Nm/° 99Nm/° 50Nm/° 1184g/398g 7
the only information i could find on the six13 is when the caad7 frame was tested but i'll put it up anyway. i have read that the newer caad8 frame is supposed to be lighter than the caad7 frame but i can't find any stiffness numbers. cannondales website has the new six13 frame weight at 1190g & the synapse at 1090g.
Cannondale Six/13 premium carbon 60Pts 68Nm/° 91Nm/° 44Nm/° 1340g/326g 7
whew. now with all that said, i own a synapse and i rode the six/13 and the r5000 caad8 before buying my synapse (back to back, 15 miles each, exact same route). truthfully i couldnt tell much af a difference between any of them. i wanted carbon, i liked the way the black synapse looked so i went with it. just dont be fooled by the relaxed/comfort claims.