cardiovascular disease (CVD) / iron

Discussion in 'Health and medical' started by doe, May 7, 2004.

  1. doe

    doe Guest

    iron-mediated oxidation of LDL may be a significant factor in the progression
    of CVD

    Fam Med. 2004 May;36(5):324-9. Links

    The combined effect of transferrin saturation and low density lipoprotein on

    Wells BJ, Mainous AG, King DE, Gill JM, Carek PJ, Geesey ME.

    Department of Family Medicine, Medical University of South Carolina.

    BACKGROUND AND OBJECTIVES: Evidence suggests that cardiovascular disease (CVD)
    is accelerated by the oxidation of low-density lipoprotein (LDL) in the
    presence of iron. This study examined whether adults with elevated iron, as
    measured by transferrin saturation (TS), and elevated LDL are at an increased
    risk for mortality. METHODS: This is a cohort study of the adult US population
    using the National Health and Nutrition Examination Survey 1976-1980 (NHANES
    II) merged with the NHANES II Mortality Study in 1992. Multivariate Cox
    regression was performed to determine hazard ratios (HR) for CVD and all-cause
    mortality for high (>55%) or low (<55%) levels of TS and high (>160mg/dl) or
    low (<160mg/dl) levels of LDL. RESULTS: An elevated LDL alone did not
    significantly increase CVD mortality or all-cause mortality in the adjusted
    model. Individuals with elevated LDL and elevated TS had a statistically
    significant increase in both CVD mortality and all-cause mortality (HR=5.74 and
    3.53, respectively) compared to the low LDL and low TS group. CONCLUSIONS: The
    results of this study indicate an increased risk associated with the
    combination of elevated LDL and elevated TS, which suggests that iron-mediated
    oxidation of LDL may be a significant factor in the progression of CVD.

    PMID: 15129378 [PubMed]


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