Chelation of free iron in nephrotic syndrome

Discussion in 'Food and nutrition' started by [email protected], Nov 30, 2005.

  1. 1: Clin Chim Acta. 2005 May;355(1-2):91-6. Related Articles, Links


    Reduction of urinary thiols in nephrotic syndrome--a possible effect of
    free iron.

    Sinha I, Ghosh S, Dey P, Jacob J, Banerjee D.

    Department of Biochemistry, Kasturba Medical College, Manipal-576104,
    Karnataka State, India.

    BACKGROUND: Albumin is a potent antioxidant as it chelates transitional
    metals and contains antioxidants like thiol and bilirubin. In neprotic
    syndrome, the defining parameter is proteinuria with hypoalbuminemia.
    Therefore albuminuria in nephrotic syndrome may increase toxic
    transitional metal ions and also can cause loss of albumin associated
    antioxidants causing oxidative stress to the individual. METHODS: We
    investigated this possibility and estimated some markers of oxidative
    stress in 20 nephrotic syndrome patients and healthy controls along
    with urinary thiols, urinary bilirubin and plasma free iron in both
    cases and in the controls. RESULT: We found oxidative stress in 20
    nephrotic syndrome patients and the markers of oxidative stress
    correlated significantly with proteinuria, but the urine of nephrotic
    syndrome patients (28.33+/-4.2 micromol/g creatinine)contained
    significantly less thiols compared to the healthy controls
    (88.45+/-10.6 micromol/g creatinine) and no biliribin. The patients
    plasma also showed free iron (0.7+/-0.05 micromol/l), a parameter
    undetectable in the healthy controls. CONCLUSION: We suggest that
    oxidative stress and presence of free iron in the patients were
    responsible for less thioluria and no bilirubinuria. A detailed study
    of oxidative biology in a large cohort of nephrotic syndrome patients
    is necessary to confirm the presence of free iron as appropriate
    chelation of free iron may benefit the long-term prognosis of the
    disease.

    PMID: 15820482 [PubMed - indexed for MEDLINE]

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