Colnago c64 setup advice

Nice to virtually meet everyone,

In the process of getting my hands on a C64, I have not been keeping up with technology and trying to gather preferences and why.

Any thoughts on the following:

Carbon Wheelset recommendations?
Dura Ace or Ultegra to save a few bucks?
Disc or Rim brakes?
Tubeless or Clinchers?
SpeedPlay or Shimano pedals?
Headset --> Stem --> Handlebar setup?
Cranks?
Other Accessories?

I ride roughly 150-200 miles a week, weekdays are flats and weekends are climbs.
I’m 5’11” with a slightly larger torso and as I’ve gotten older my setup is less aero than it used to be.
I want the my ride to be stiff, but not harsh/uncomfortable.
I'm not obsessed with bike weight, but try to keep it as light as possible without sacrificing quality/durability.

Thank you in advance!