completely reversing Osteoradionecrosis

Discussion in 'Health and medical' started by Doe, Jan 27, 2004.

  1. Doe

    Doe Guest

    >>snip<<
    In these reactions iron plays an important role suggesting that the selective in vitro antioxidant
    properties of the bisphosphonates are due to their iron chelating characteristics.
    >>snip<<

    Biochem Biophys Res Commun. 2004 Feb 13; 314(3): 675-80. Related Articles, Links

    Selective in vitro antioxidant properties of bisphosphonates.

    Dombrecht EJ, Cos P, Berghe DV, Offel JF, Schuerwegh AJ, Bridts CH, Stevens WJ, De Clerck LS.

    Laboratory of Immunology, Allergology and Rheumatology, Department of Medicine, University of
    Antwerp, Universiteitsplein 1, B-2610, Antwerp, Belgium

    The aim of this study was to investigate the in vitro antioxidant profile of different
    bisphosphonates. Bisphosphonates were tested for their xanthine oxidase and microsomal lipid
    peroxidation inhibiting capacity. Furthermore, the

    effect of these different compounds on DPPH, a stable radical, was investigated. Clodronate,
    risedronate, and pyrophosphate were further tested for their hydroxyl radical scavenging activity.
    None of the tested compounds showed xanthine oxidase inhibiting activity or DPPH scavenging
    activity. All the tested bisphosphonates exhibited inhibiting capacities on the microsomal lipid
    peroxidation. The hydroxyl radical scavenging activity was dependent on the order of adding the
    different reagents and was highest for risedronate. Bisphosphonates possess an inhibiting activity
    on the microsomal lipid peroxidation and the Fenton reaction. In these reactions iron plays an
    important role suggesting that the selective in vitro antioxidant properties of the bisphosphonates
    are due to

    their iron chelating characteristics.

    PMID: 14741688 [PubMed - in process]

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    Br J Radiol. 2002 May; 75(893): 467-9. Related Articles, Links


    Complete healing of severe osteoradionecrosis with treatment combining
    pentoxifylline, tocopherol and clodronate.

    Delanian S, Lefaix JL.

    Service d'Oncologie-Radiotherapie, Hopital Saint-Louis APHP, 1 Ave Claude
    Vellefaux, 75010 Paris, France.

    Osteoradionecrosis (ORN) is a late terminal sequela of irradiation that does
    not resolve spontaneously. In a preliminary study, a combination of
    pentoxifylline (PTX), tocopherol (Vit-E) and clodonate has been shown to be of
    clinical
    benefit with more than 50% regression of progressive ORN observed at 6 months
    in 12 patients. A 68-year-old woman presenting with severe exteriorized
    osteoradionecrosis had received radiotherapy for breast cancer 29 years
    previously.
    She had palpable breast fibrosis, including the sternum (15 cm x 11 cm) and a
    painful fistulous track in the upper part of the bone (orifice diameter 10 mm)
    surrounded by local inflammatory signs, and chronic osteitis with sequestra
    extrusion. MRI showed deep radiation-induced fibrosis below this area without
    cancer recurrence, and complete bone destruction over an area of 7 cm x 4 cm.
    Oral PTX (800 mg day(-1)), Vit.E (1000 IU day(-1)) and clodronate (1600 mg
    day(-1)) were administered daily for 3 years and were well tolerated. The
    patient
    exhibited regular clinical improvement until complete closure of the fistula
    and total regression of the clinical fibrosis. MRI confirmed the good response
    and showed heterogeneous restoration of the sternum, which was filled with new
    tissue. This is the first time that antifibrotic treatment with combined
    PTX-Vit.E plus clodronate has been shown to have a significant effect on
    necrosis,
    by completely reversing severe progressive ORN and the associated
    radiation-induced fibrosis.

    Publication Types:
    Case Reports

    PMID: 12036843 [PubMed - indexed for MEDLINE]

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