No it is not unsafe, just different. As riding one bike with twitchier handling. Like the difference between getting on one bike that has twitchy handling vs a bike that does not. You get used to it and it adapt. It's not unsafe at all, just a little more grippy.
Like I mentioned, the difference between riding a road bike and a mtb down a mountain road in switch backs, it's not dangerous on either one if you know what to expect and how to handle the bike.
Plus it is not that dramatic, I used that to explain the difference I felt in the tire.
Now to be dangerous, are you saying that if I ride a mtb down a mountain road, that is dangerous? You're too funny. I've been riding long enough to know the handling on the 2 bikes are different and I'm not going to crash because one handles differently. Heck, my Madone handles differently from the Lemond Chambery I had, which was different handling from my Cannondale. All 3 handled differently. The Madone has a twitchy feeling much like the 5000 tire. I'm still alive and haven't crashed because of the different feeling between the 3. NO, it is not dangerous, just different as explained.
Think about it, a deep profile rim (30mm) feels different in the wind vs a shallow rim (23 mm). My 30 mm rims catch the wind more than some of the others I have ridden. That feeling of the wind hitting the rim from the side makes the rim feel different. I've been riding 30 mm rims for 23 years. It's the same difference, and never has it been dangerous.
I just rode on a really windy day yesterday. The feeling of the side wind was far more dramatic than the feeling of the 5000. I guess I shouldn't ride in the wind any longer? NOT! If one knows how to adapt and handle a bike, it is not a problem.