S
This review study (?) suggests that even periodical CR may prevent
breast cancer.
Arbor
Obes Rev. 2006 Feb;7(1):33-47. Links
Energy balance adiposity and breast cancer - energy restriction
strategies for breast cancer prevention.
Harvie M, Howell A.
CRUK University Department of Medical Oncology, Christie Hospital,
Manchester, UK.
Excess adiposity over the pre- and postmenopausal years is linked to
risk of postmenopausal breast cancer. Weight loss could potentially
reduce risk amongst those with excess weight via beneficial effects on
the hormonal (decreased circulating levels of oestradiol, testosterone,
insulin) and secretory profiles of adipocytes (decreased production of
leptin, tumour necrosis factor-alpha, interleukin 6 and increased
production of adiponectin). Only modest reductions in adipose tissue
are achieved and sustained with current weight loss programmes, which
makes strategies to mitigate the adverse metabolic effect of adiposity
a priority for cancer prevention. The adverse hormonal and secretory
effects of adipose tissue are influenced substantially by acute changes
in energy balance prior to changes in adiposity. Human and animal
studies have shown dietary energy restriction to bring about favourable
changes in circulating levels of insulin, leptin, sex hormone binding
globulin, insulin-like growth factor-1, oestradiol, testosterone,
reactive oxygen species, and the production and secretion of locally
acting adipokines and inflammatory cytokines, that is, increased
adiponectin and decreased interleukin-6. Achieving and sustaining
energy restriction remains a difficult challenge. Intermittent energy
restriction is a potential strategy for promoting periods of energy
restriction on a long-term basis. Animal and human data suggest that
intermittent energy restriction may have cancer preventative effects
beyond that of chronic energy restriction and weight loss. Intermittent
energy restriction may be a potential strategy for the primary
prevention of breast cancer.
PMID: 16436101 [PubMed - in process]
breast cancer.
Arbor
Obes Rev. 2006 Feb;7(1):33-47. Links
Energy balance adiposity and breast cancer - energy restriction
strategies for breast cancer prevention.
Harvie M, Howell A.
CRUK University Department of Medical Oncology, Christie Hospital,
Manchester, UK.
Excess adiposity over the pre- and postmenopausal years is linked to
risk of postmenopausal breast cancer. Weight loss could potentially
reduce risk amongst those with excess weight via beneficial effects on
the hormonal (decreased circulating levels of oestradiol, testosterone,
insulin) and secretory profiles of adipocytes (decreased production of
leptin, tumour necrosis factor-alpha, interleukin 6 and increased
production of adiponectin). Only modest reductions in adipose tissue
are achieved and sustained with current weight loss programmes, which
makes strategies to mitigate the adverse metabolic effect of adiposity
a priority for cancer prevention. The adverse hormonal and secretory
effects of adipose tissue are influenced substantially by acute changes
in energy balance prior to changes in adiposity. Human and animal
studies have shown dietary energy restriction to bring about favourable
changes in circulating levels of insulin, leptin, sex hormone binding
globulin, insulin-like growth factor-1, oestradiol, testosterone,
reactive oxygen species, and the production and secretion of locally
acting adipokines and inflammatory cytokines, that is, increased
adiponectin and decreased interleukin-6. Achieving and sustaining
energy restriction remains a difficult challenge. Intermittent energy
restriction is a potential strategy for promoting periods of energy
restriction on a long-term basis. Animal and human data suggest that
intermittent energy restriction may have cancer preventative effects
beyond that of chronic energy restriction and weight loss. Intermittent
energy restriction may be a potential strategy for the primary
prevention of breast cancer.
PMID: 16436101 [PubMed - in process]