Critical role for iron in neurodegeneration

Discussion in 'Food and nutrition' started by [email protected], Mar 28, 2006.

  1. Iron dysregulation and neurodegeneration: the molecular connection.
    Lee DW, Andersen JK, Kaur D
    Mol Interv. 2006 Apr ; 6(2): 89-97

    Iron is essential for many biological processes however excess
    concentrations can be harmful to many tissues. Its amounts must
    therefore be carefully regulated in all cells of the body including
    those in the brain. Increased amounts of iron have been reported in
    many neurodegenerative disorders. Whether this increased iron
    contributes to neurodegeneration has been considered controversial. In
    this review, we discuss some recently identified anomalies in proteins
    linked with iron metabolism which signify a critical role for iron
    dysregulation in neurodegeneration

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