Current prospects for controlling cancer growth with non-cytotoxic agents

Discussion in 'Health and medical' started by Roger, Feb 27, 2004.

  1. Roger

    Roger Guest

    Med Hypotheses. 2001 Feb;56(2):137-54.

    Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients,
    phytochemicals, herbal extracts, and available drugs.

    McCarty MF.

    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA.

    In animal or cell culture studies, the growth and spread of cancer can be slowed by many nutrients,
    food factors, herbal extracts, and well-tolerated, available drugs that are still rarely used in the
    clinical management of cancer, in part because they seem unlikely to constitute definitive therapies
    in themselves. However, it is reasonable to expect that mechanistically complementary combinations
    of these measures could have a worthwhile impact on survival times and, when used as adjuvants,
    could improve the cure rates achievable with standard therapies. The therapeutic options available
    in this regard include measures that: down-regulate serum free IGF-I; suppress the synthesis of
    mevalonic acid [note from poster: that's why statins are useful against cancer] and/or certain
    derivatives thereof; modulate arachidonate metabolism by inhibiting 5-lipoxygenase, 12-lipoxygenase,
    or COX-2; antagonize the activation of AP-1 transcription factors; promote the activation of PPAR-
    gamma transcription factors; and that suppress angiogenesis by additional mechanisms. Many of these
    measures appear suitable for use in cancer prevention.