depression / oxidative stress

Discussion in 'Health and medical' started by Doe, Feb 28, 2004.

  1. Doe

    Doe Guest

    Redox Rep. 2003;8(6):365-70. Related Articles, Links

    Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-
    uptake inhibitors.

    Khanzode SD, Dakhale GN, Khanzode SS, Saoji A, Palasodkar R.

    Department of Pharmacology, Government Medical College, Nagpur, India. [email protected]

    There is evidence of derangement of oxidant and antioxidant defense systems in depression. The
    present study examined the effects of fluoxetine and citalopram, standard selective serotonin re-
    uptake inhibitors, on lipid peroxidation, superoxide dismutase (SOD) activity and ascorbic acid
    concentrations. For this, a prospective open-labeled, randomized design was utilized. Patients with
    major depression (n = 62) were compared with age- and

    serum SOD, serum MDA and decrease in plasma ascorbic acid levels in patients of major depression as
    compared to control subjects. The trend reversed significantly after treatment with fluoxetine and
    citalopram. Results indicate a greater reduction in oxidative stress with citalopram than
    fluoxetine. The Hamilton Rating Scale for Depression (HRSD) score also improved with fluoxetine and
    citalopram treatment. These findings indicate that major depression is associated with increased
    levels of serum SOD, serum MDA and decreased levels of plasma ascorbic acid. Treatment with
    fluoxetine and citalopram reversed these biochemical parameters. This study can be used as a
    predictor of drug response by fluoxetine and citalopram in major depression.

    PMID: 14980069 [PubMed - in process]

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  2. Doe

    Doe Guest

    >Subject: depression / oxidative stress
    >From: [email protected] (doe)
    >Date: 2/28/2004 9:57 AM Mountain Standard Time
    >Message-id: <[email protected]>
    >
    >Redox Rep. 2003;8(6):365-70. Related Articles, Links
    >
    >
    >Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-
    >uptake inhibitors.
    >
    >Khanzode SD, Dakhale GN, Khanzode SS, Saoji A, Palasodkar R.
    >
    >Department of Pharmacology, Government Medical College, Nagpur, India.
    >[email protected]
    >
    >There is evidence of derangement of oxidant and antioxidant defense systems in depression. The
    >present study examined the effects of fluoxetine and citalopram, standard selective serotonin re-
    >uptake inhibitors, on lipid peroxidation, superoxide dismutase (SOD) activity and ascorbic acid
    >concentrations. For this, a prospective open-labeled, randomized design was utilized. Patients with
    >major depression (n = 62) were compared with age- and

    >serum SOD, serum MDA and decrease in plasma ascorbic acid levels in patients of major depression as
    >compared to control subjects. The trend reversed significantly after treatment with fluoxetine and
    >citalopram. Results indicate a greater reduction in oxidative stress with citalopram than
    >fluoxetine. The Hamilton Rating Scale for Depression (HRSD) score also improved with fluoxetine and
    >citalopram treatment. These findings indicate that major depression is associated with increased
    >levels of serum SOD, serum MDA and decreased levels of plasma ascorbic acid. Treatment with
    >fluoxetine and citalopram reversed these biochemical parameters. This study can be used as a
    >predictor of drug response by fluoxetine and citalopram in major depression.
    >
    >PMID: 14980069 [PubMed - in process]
    >
    >---------------------------------------------

    http://tinyurl.com/36y9f

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