Diabetic retinopathy / oxidative stress

Discussion in 'Food and nutrition' started by [email protected], Feb 6, 2006.

  1. [Oxidative stress in a model of experimental diabetic retinopathy: the
    utility of peroxinytrite scavengers.]
    Miranda M, Muriach M, Roma J, Bosch-Morell F, Genovés JM, Barcia J,
    Araiz J, Díaz-Llospis M, Romero FJ
    Arch Soc Esp Oftalmol. 2006 Jan ; 81(1): 27-32

    PURPOSE: The retina is the neurosensorial tissue of the eye and is
    extremely rich in polyunsaturated lipid membranes. This feature makes
    it especially sensitive to oxygen and/or nitrogen activated species and
    lipid peroxidation. Several authors have postulated the importance of
    superoxide (O(-)(2)) and peroxynitrite production in the development of
    diabetic complications. In the present study, we have used two
    different antioxidants, ebselen and lutein, that present as a common
    feature their peroxynitrite scavenging capacity, to ameliorate the
    oxidative stress that exists in the retina in diabetic patients.
    METHODS: Hyperglycemia was accomplished by the intraperitoneal
    injection of Alloxan in a mouse model of diabetic retinopathy.
    Malondialdehyde (MDA) and glutathione (GSH) concentrations in eye
    homogenates (without the lens) were determined. We also recorded serial
    electroretinograms (ERG) and measured latency and implicit times.
    RESULTS: The MDA concentration increased and the GSH concentration
    decreased in the eyes of the diabetic animals. Treatment with ebselen
    and lutein restored the MDA and GSH concentrations to control values.
    Latency and implicit times were not affected by the diabetes.
    CONCLUSION: New studies are required to better understand the
    protective mechanism of ebselen and lutein in this model of
    experimental diabetic retinopathy (Arch Soc Esp Oftalmol 2006; 81:
    27-32).

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