I
[Oxidative stress in a model of experimental diabetic retinopathy: the
utility of peroxinytrite scavengers.]
Miranda M, Muriach M, Roma J, Bosch-Morell F, Genovés JM, Barcia J,
Araiz J, Díaz-Llospis M, Romero FJ
Arch Soc Esp Oftalmol. 2006 Jan ; 81(1): 27-32
PURPOSE: The retina is the neurosensorial tissue of the eye and is
extremely rich in polyunsaturated lipid membranes. This feature makes
it especially sensitive to oxygen and/or nitrogen activated species and
lipid peroxidation. Several authors have postulated the importance of
superoxide (O(-)(2)) and peroxynitrite production in the development of
diabetic complications. In the present study, we have used two
different antioxidants, ebselen and lutein, that present as a common
feature their peroxynitrite scavenging capacity, to ameliorate the
oxidative stress that exists in the retina in diabetic patients.
METHODS: Hyperglycemia was accomplished by the intraperitoneal
injection of Alloxan in a mouse model of diabetic retinopathy.
Malondialdehyde (MDA) and glutathione (GSH) concentrations in eye
homogenates (without the lens) were determined. We also recorded serial
electroretinograms (ERG) and measured latency and implicit times.
RESULTS: The MDA concentration increased and the GSH concentration
decreased in the eyes of the diabetic animals. Treatment with ebselen
and lutein restored the MDA and GSH concentrations to control values.
Latency and implicit times were not affected by the diabetes.
CONCLUSION: New studies are required to better understand the
protective mechanism of ebselen and lutein in this model of
experimental diabetic retinopathy (Arch Soc Esp Oftalmol 2006; 81:
27-32).
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utility of peroxinytrite scavengers.]
Miranda M, Muriach M, Roma J, Bosch-Morell F, Genovés JM, Barcia J,
Araiz J, Díaz-Llospis M, Romero FJ
Arch Soc Esp Oftalmol. 2006 Jan ; 81(1): 27-32
PURPOSE: The retina is the neurosensorial tissue of the eye and is
extremely rich in polyunsaturated lipid membranes. This feature makes
it especially sensitive to oxygen and/or nitrogen activated species and
lipid peroxidation. Several authors have postulated the importance of
superoxide (O(-)(2)) and peroxynitrite production in the development of
diabetic complications. In the present study, we have used two
different antioxidants, ebselen and lutein, that present as a common
feature their peroxynitrite scavenging capacity, to ameliorate the
oxidative stress that exists in the retina in diabetic patients.
METHODS: Hyperglycemia was accomplished by the intraperitoneal
injection of Alloxan in a mouse model of diabetic retinopathy.
Malondialdehyde (MDA) and glutathione (GSH) concentrations in eye
homogenates (without the lens) were determined. We also recorded serial
electroretinograms (ERG) and measured latency and implicit times.
RESULTS: The MDA concentration increased and the GSH concentration
decreased in the eyes of the diabetic animals. Treatment with ebselen
and lutein restored the MDA and GSH concentrations to control values.
Latency and implicit times were not affected by the diabetes.
CONCLUSION: New studies are required to better understand the
protective mechanism of ebselen and lutein in this model of
experimental diabetic retinopathy (Arch Soc Esp Oftalmol 2006; 81:
27-32).
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking