DNA damage / antioxidative status / vegetarians

Discussion in 'Health and medical' started by Doe, Mar 15, 2004.

  1. Doe

    Doe Guest

    Neoplasma. 2004;51(1):30-3. Links

    Oxidative DNA damage in relation to nutrition.

    Krajcovicova-Kudlackova M, Dusinska M.

    Institute of Preventive and Clinical Medicine;, Bratislava,
    833 01 Slovak Republic. [email protected]

    Oxidative DNA damage in humans could arise also from
    incorrect nutritional habit and life style. DNA strand
    breaks with apurinic/apyrimidinic sites, oxidized purines
    and oxidized pyrimidines were assessed in 24 subjectively
    healthy vegetarians (plant food, dairy products, eggs) and
    compared with 24 non-vegetarians (traditional diet, general
    population). DNA strand breaks + oxidized purines are
    significantly reduced in vegetarians (p<0.05), DNA strand
    breaks are nonsignificantly decreased. The sufficient
    antioxidative status (overthreshold values of natural
    essential antioxidants, which mean a reduced risk of free
    radical disease) is crucial in free radical defense. Intake
    of protective food commodities (fruit, vegetables, dark
    grain products, grain sprouts, oil seeds) is significantly
    higher in vegetarians. Alternative nutrition subjects have a
    significantly increased plasma levels of vitamin C, vitamin
    E, beta-carotene with high incidence of overthreshold values
    (92% vs. 42% - vitamin C, 67% vs. 33% - vitamin E, 67% vs.
    17% - beta-carotene). There is recorded a significant
    inverse linear correlation between values of DNA strand
    breaks + oxidized purines and vitamin C or beta-carotene
    levels (p<0.01, p<0.05). Vegetarian diet is significantly
    more rich source of antioxidants. The results of reduced
    endogenous DNA damage and higher antioxidative status in
    vegetarians document that a correct vegetarian nutrition
    might represent an effective cancer prevention.

    PMID: 15004656 [PubMed - in process]


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