Don't give me no LIP / labile iron pool

Discussion in 'Health and medical' started by Doe, Feb 21, 2004.

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    Med Hypotheses. 2004 Mar;62(3):442-5. Related Articles, Links

    Serum markers of stored body iron are not appropriate markers of health effects of iron: a focus on
    serum ferritin.

    Lee DH, Jacobs DR Jr.

    Experimental studies have consistently shown that iron is a critical catalyst in generating oxygen
    free radicals via Fenton chemistry. Nevertheless, epidemiologic studies conflict on the association
    between stored body iron markers and disease outcomes, including coronary heart disease. We
    hypothesize that stored body iron markers common in epidemiologic studies, such as serum ferritin,
    transferrin saturation, iron, or iron-binding capacity, are inappropriate to investigate harmful
    health effects related to iron overload. Oxygen free radicals are produced only by free iron, but
    stored body iron markers reflect iron bound to ferritin or transferrin, which are produced to
    sequester catalytically active free iron. Moreover, increased serum ferritin may occur as a defense
    mechanism in response to oxidative stress; such increase might eventually minimize oxidative stress
    and consequent pathology due to free iron. Therefore, though highly correlated with stored body
    iron, a measure of bound iron will fail to identify any harmful effect, unless it is also a marker
    of free iron. It is generally believed that free iron rarely exists, except in iron-overload with
    100% transferrin saturation. However, some recent studies find non-transferrin bound iron (NTBI) or
    the intracellular labile iron pool
    (LIP) in the presence of triggers disturbing iron homeostasis, such as alcohol consumption. In
    contrast to the tight bond in ferritin or transferrin, free iron is more likely to dissociate
    from a looser bond. Therefore research on the relation of iron with disease outcomes should
    investigate NTBI or the intracellular LIP. Any positive influence of iron on coronary heart
    and other diseases might be observable only when a trigger is present. These factors may
    explain why there have been conflicting results between serum markers of stored body iron and
    disease outcomes in epidemiological studies.

    PMID: 14975519 [PubMed - in process]


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