So since an increase in red blood cell mass in these .. dogs .. causes them to drink excessively and
urinate excessively .. hmm .. somewhat like .. Beav .. would / could the fact the number of people
with diabetes who drink excessively and urinate excessively be ALSO related to the fact they have
elevated red blood cell mass?
As evidenced by the increase of blood flow in those diabetics given iron chelators .. which lower
the red blood cell mass .. no iron .. no red blood cells .
This increases the flow of blood .. allowing it to flow further and faster / no stasis ..
<<snip>> We conclude that blood hyperviscosity and increased blood volume led to impaired VP release
and polyuria. <<snip>>
: J Vet Intern Med 1997 Sep-Oct;11(5):300-3 Related Articles, Links
Polyuria and polydipsia and disturbed vasopressin release in 2 dogs with secondary polycythemia.
van Vonderen IK, Meyer HP, Kraus JS, Kooistra HS.
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht
University, The Netherlands.
In dogs, secondary polycythemia (SP) may be associated with polyuria and polydipsia (PU/PD). The
pathogenesis of this PU/PD has not yet been explained. We hypothesized that hyperviscosity and
increased blood volume in SP might affect vasopressin (VP) release, resulting in PU/PD. This
hypothesis was tested in 2 dogs with SP caused by renal neoplasia and PU/PD. Osmoregulation of VP
release was studied by a modified water deprivation test and by investigating the VP response to
hypertonic saline infusion. Water deprivation test results were consistent with an inability to
produce concentrated urine despite increasing plasma osmolality. During hypertonic saline infusion,
the osmotic threshold of VP release was markedly increased in both dogs, resulting in a delayed VP
response to increasing plasma osmolality. The sensitivity of VP release was low normal in both
dogs. We conclude that blood hyperviscosity and increased blood volume led to impaired VP release
and polyuria.
PMID: 9348498 [PubMed - indexed for MEDLINE]
This article clearly shows the effects of too many red blood cells {polycythemia] in those with
diabetes. The effects here were CREATED by the doctors during the treatment .. giving them iron to
treat their anemia ..
<<snip>> Complications during the period of polycythemia included gangrenous feet requiring
amputation in 2 patients, CVA in 2 patients, and splenic infarct in 1 patient. One patient died
of cerebral thrombosis. We conclude that polycythemia is uncommon in CAPD patients and occurs
most often in diabetic patients. Volume depletion and iron therapy may play a role in its
etiology <<snip>>
Adv Perit Dial 1991;7:77-80
Polycythemia in diabetic patients on CAPD.
Bender FH, Piraino B Department of Medicine, University of Pittsburgh, PA.
Polycythemia in CAPD patients has been rarely described. Over an eight year period, 4 out of 123
CAPD patients (3%) were identified as having Hct values exceeding 50% for 1 month or longer. All of
the 4 patients were insulin dependent diabetics (4/47 diabetic patients, 8.5%). Charts were reviewed
on 3 of these 4 patients. Polycythemia developed after a mean of 21 +/- 7 months on peritoneal
dialysis. Prior to the development of polycythemia, ferritin levels were low and ferrous sulfate
therapy was begun at a time the Hct values were 36 to 40%. Erythropoietin levels were obtained in 2
patients, and were 22 U/L (Hct 51%) and less than 5 U/L (Hct 55%). Renal ultrasound failed to show
renal masses or cysts. One patient had a plasma volume of 2.1 L (normal 2.4-3.2 L); another patient
was clinically volume depleted. Complications during the period of polycythemia included gangrenous
feet requiring amputation in 2 patients, CVA in 2 patients, and splenic infarct in 1 patient. One
patient died of cerebral thrombosis. We conclude that polycythemia is uncommon in CAPD patients and
occurs most often in diabetic patients. Volume depletion and iron therapy may play a role in its
etiology. In this high risk group of patients polycythemia may contribute to vascular complications
and should be avoided.
PMID: 1680462, UI: 92002272
----------------------------------------------------------------------------
----
Who loves ya. Tom
--
Jesus Was A Vegetarian! jesuswasavegetarian.7h.comjesuswasavegetarian.7h.comOpen ↗ Man Is A Herbivore!
pages.ivillage.commanisaherbivoreOpen ↗