Echinochrome, a naturally occurring iron chelator



Vestn Oftalmol. 1999 Mar-Apr;115(2):34-5. Related Articles, Links

[Histochrome, a new antioxidant, in the treatment of ocular diseases]

[Article in Russian]

Egorov EA, Alekhina VA, Volobueva TM, Fedoreev SA, Mishchenko NP, Kol'tsova EA.

The efficacy of a new bioantioxidant histochrome is studied in 92 patients (98
eyes). The drug was injected subconjunctivally or parabulbarly in a dose of 0.5
ml 0.02% solution daily, 7-10 injections per course. The clinical effect of
histochrome is determined by the localization, duration, and extent of the
process. The drug was the most effective in the treatment of intraocular
hemorrhages which occurred no more than 7 days before. Electroretinography
demonstrated pronounced retinoprotective properties of the drug which improved
the electrophysiological parameters in degenerative processes in the retina and
optic nerve. Hence, histochrome is characterized by hemoresorption,
retinoprotective, and antioxidant properties and is recommended for the
treatment of ocular diseases involving metabolic disorders in the retina,
vascular membrane, and cornea.

PMID: 10377874 [PubMed - indexed for MEDLINE]


Life Sci. 2005 Jan 7;76(8):863-75. Related Articles, Links

Echinochrome, a naturally occurring iron chelator and free radical scavenger in
artificial and natural membrane systems.

Lebedev AV, Ivanova MV, Levitsky DO.

Institute of Experimental Cardiology, Cardiology Research Center, Russian
Ministry of Health, 3rd Cherepkovskaya ul. 15a, Moscow, 112552 Russia.

Echinochrome, or 6-ethyl-2,3,5,7,8-pentahydroxy-1,4-naphthoquinone, possesses
cardioprotective activity, and diminishes the myocardial ischemia/reperfusion
injury that is known to be accompanied by free-radical oxidative damage and
calcium overload. In this study, we investigated the lipophilicity of
echinochrome, its ability to inhibit free-radical oxidation both in the bulk
organic phase and in an artificial membrane system (liposomes), and to prevent
the ferrous/ascorbate-induced leakage of calcium from the isolated sarcoplasmic
reticulum (SR) of rabbit skeletal muscle. The experimentally-determined
octanol/water partition coefficient (LogP) of echinochrome was +3.11, and the
distribution coefficient (LogD) was +2.58 at pH 6.0 and -0.15 at pH 8.0.
Echinochrome displayed high scavenging activity against
1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals with a stoichiometry of about
1:7. Echinochrome was more effective in inhibiting the phosphatidyl choline
liposome peroxidation induced by Fe(2+)/ascorbate than that induced by hemin.
The iron chelating ability of echinochrome was estimated
spectrophotometrically. In isolated SR, echinochrome protected the
ATP-dependent Ca(2+)-pump system from damage by Fe(2+)/ascorbate. It was
concluded that iron chelation predominates in the overall antioxidant potential
of echinochrome.

PMID: 15589964 [PubMed - in process]


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