Effects of iron infusion / kidney and liver

Discussion in 'Food and nutrition' started by [email protected], Apr 9, 2005.

  1. Biofactors. 2005;23(1):35-44. Related Articles, Links


    Lipid peroxidation in plasma of rats treated with
    ferric-nitrilotriacetate, in relation to kidney and liver
    modifications.

    Deiana M, Rosa A, Corona G, Collu S, Ennas MG, Dessi MA.

    Dipartimento di Biologia Sperimentale, Sezione di Patologia
    Sperimentale, Universita degli Studi di Cagliari, Cittadella
    Universitaria SS 554, 09042 Monserrato, Cagliari, Italy.

    Intraperitoneal injection of the iron chelate ferric-nitrilotriacetate
    (Fe-NTA) induces in rodents renal and hepatic suffering, associated
    with oxidative damage. We investigated the oxidation pattern in plasma
    of treated rats in relation to liver and kidney, monitoring the
    variation of the lipid components more susceptible to oxidation,
    unsaturated fatty acids (UFA) and alpha-tocopherol, as biomarkers of
    the oxidative damage. A sublethal dose of Fe-NTA induced a strong and
    extremely significant decrease of UFA levels at 1 h after injection in
    the plasma compartment and at 3 h in the kidney, with reductions up to
    40-50% of the control values, together with an increase of conjugated
    dienes fatty acids hydroperoxides and a consumption of
    alpha-tocopherol. The same modifications were observed in the liver,
    but to a lesser extent. Histological observation proved that
    biochemical changes in the lipid fraction were a direct consequence of
    an ongoing membrane lipid peroxidation process. Our data show that
    oxidative damage to the lipid fraction is initially evident in the
    plasma compartment, where Fe-NTA toxicity is assumed to be caused by
    the elevation of serum free iron concentration, and proceeds with
    different speed and severity in the kidney and liver.

    PMID: 15817997 [PubMed - in process]

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