Effects of iron infusion / kidney and liver



Biofactors. 2005;23(1):35-44. Related Articles, Links


Lipid peroxidation in plasma of rats treated with
ferric-nitrilotriacetate, in relation to kidney and liver
modifications.

Deiana M, Rosa A, Corona G, Collu S, Ennas MG, Dessi MA.

Dipartimento di Biologia Sperimentale, Sezione di Patologia
Sperimentale, Universita degli Studi di Cagliari, Cittadella
Universitaria SS 554, 09042 Monserrato, Cagliari, Italy.

Intraperitoneal injection of the iron chelate ferric-nitrilotriacetate
(Fe-NTA) induces in rodents renal and hepatic suffering, associated
with oxidative damage. We investigated the oxidation pattern in plasma
of treated rats in relation to liver and kidney, monitoring the
variation of the lipid components more susceptible to oxidation,
unsaturated fatty acids (UFA) and alpha-tocopherol, as biomarkers of
the oxidative damage. A sublethal dose of Fe-NTA induced a strong and
extremely significant decrease of UFA levels at 1 h after injection in
the plasma compartment and at 3 h in the kidney, with reductions up to
40-50% of the control values, together with an increase of conjugated
dienes fatty acids hydroperoxides and a consumption of
alpha-tocopherol. The same modifications were observed in the liver,
but to a lesser extent. Histological observation proved that
biochemical changes in the lipid fraction were a direct consequence of
an ongoing membrane lipid peroxidation process. Our data show that
oxidative damage to the lipid fraction is initially evident in the
plasma compartment, where Fe-NTA toxicity is assumed to be caused by
the elevation of serum free iron concentration, and proceeds with
different speed and severity in the kidney and liver.

PMID: 15817997 [PubMed - in process]

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