Electron microscopy showed iron within synovial cells

Discussion in 'Food and nutrition' started by Doe, Nov 27, 2003.

  1. Doe

    Doe Guest

    Arthritis Rheum 1981 May;24(5):706-10

    Clearance of calcium pyrophosphate dihydrate crystals in vivo. III. Effects of synovial
    hemosiderosis.

    McCarty DJ, Palmer DW, Garancis JC Synthetic triclinic calcium pyrophosphate dihydrate crystals,
    uniformly labeled with 85Sr and 45Ca, were injected into the knee joints of 2 normal adult rabbits
    and 2 rabbits previously injected repeatedly with autologous blood. The "half clearance time" of the
    injected crystal mass was 20.4 and 19 days from control joints, nearly identical to previously
    reported values in 6 rabbits
    (19.1 +/- 1.4), and 28.8 and 34 days from the joints injected with blood, a significant difference
    (P less than 0.05). Iron stains showed hemosiderin granules in the superficial synovium in these
    joints. Electron microscopy showed crystals with a molar calcium/phosphorus ratio of 1.0 and
    particles containing iron within synovial cells. We hypothesize that the decreased clearance
    rate from hemosiderotic synovium is due to inhibition of one or more intracellular
    pyrophosphatases by iron.

    PMID: 6263291, UI: 81207376

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