Elevated serum ferritin / breast cancer

Discussion in 'Health and medical' started by Doe, Feb 27, 2004.

  1. Doe

    Doe Guest

    Anticancer Res. 2003 Nov-Dec;23(6D):5107-9. Links

    Serum parameters of iron metabolism in patients with breast cancer.

    Ulbrich EJ, Lebrecht A, Schneider I, Ludwig E, Koelbl H, Hefler LA.

    Department of Obstetrics and Gynecology, Martin-Luther-University Halle-Wittenberg, Magdeburger
    Strasse 24, 06097 Halle, Germany. [email protected]

    BACKGROUND: The aim of our study was to determine the incidence of anemia as evidenced by altered
    serum levels of iron metabolism in patients with breast cancer (n = 84), ductal carcinoma in situ
    (DCIS) (n = 29), fibroadenoma (n =
    100) and healthy women (n = 14). MATERIALS AND METHODS: Hemoglobin (Hb), serum iron, serum ferritin,
    serum transferrin and serum transferrin receptor were evaluated prior to surgery. No patient
    with breast cancer had anemia according to Hb level. RESULTS: No significant correlations
    between serum iron, transferrin and transferrin receptor were ascertained. Serum ferritin was
    significantly elevated in patients with breast cancer. Among patients with breast cancer, a
    significant correlation with positive lymph node involvement was noted. CONCLUSION: Elevated
    serum ferritin might indicate the presence of malignant disease and could be regarded as a
    predictor of positive lymph node involvement in patients with breast cancer.

    PMID: 14981974 [PubMed - in process]


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