Emphysema / IRON AND OXIDATIVE STRESS

Discussion in 'Food and nutrition' started by [email protected], Mar 11, 2006.

  1. [The role of oxidative stress in the pathogenesis of pulmonary
    emphysema]
    Vucevic D, Radosavljevic T, Zunic S, Dordevic-Denic G, Pesic BC,
    Radak D
    Med Pregl. 2005 Sep-Oct ; 58(9-10): 472-7

    OXIDATIVE PULMONARY DAMAGE: The pathogenesis of pulmonary emphysema is
    incompletely understood. Nearly 90% of all patients with chronic
    obstructive pulmonary diseases are smokers. Cigarette smoke is a rich
    source of oxidants. Oxidative stress increases oxidant generation,
    which cannot be neutralized with antioxidant defense mechanisms.
    Lipids, proteins and deoxyribonucleic acid are components of the cell
    that are most sensitive to oxidative damage. Oxygen radicals can modify
    amino acid side chains, form protein aggregates, cleave peptide bonds,
    and make proteins more susceptible to proteolytic degradation. It has
    been shown that neutrophils have a principal effector role in pulmonary
    tissue damage. Neutrophil elastase can damage air spaces by degrading
    elastin, and a variety of extracellular membrane proteins,
    proteoglycans, and glycoproteins. Neutrophil elastase can also
    stimulate inflammation by increasing interleukin-8 synthesis.
    Additionally, neutrophil elastase can activate or inactivate inhibitors
    of neutrophil collagenase, and secretory leukoprotease proteinase
    inhibitor. Apart from neutrophils, oxidative stress causes activation
    of other phagocytes and severe inflammatory response ensues. LIPID
    PEROXILATION AND PULMONARY EMPHYSEMA: Except protein oxidation and
    lipid peroxidation, oxidants may disturb signal transmission in the
    cells, as well as normal cell membrane function and function of
    organelles. Modified structure of deoxyribonucleic acid may cause
    mutations, which in absence of repairation enzyme activity lead to cell
    injury. IRON AND OXIDATIVE STRESS: Iron metabolism is also important in
    the development of pulmonary emphysema due to its role in production of
    some oxidants.

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