Enhancement of absorption / lecithin



Biosci Biotechnol Biochem. 2003 Dec; 67(12): 2548-55. Related Articles, Links

Enhancing Effect of Lipids and Emulsifiers on the Accumulation of Quercetin Metabolites in Blood
Plasma after the Short-term Ingestion of Onion by Rats.

Azuma K, Ippoushi K, Ito H, Horie H, Terao J.

National Institute of Vegetable and Tea Science, National Agricultural Research Organization.

The effects of co-ingested lipids and emulsifiers on the accumulation of quercetin metabolites in
blood plasma after the short-term ingestion of onion by rats were investigated. Plasma extracts of
rats that had been fed onion-containing diets for one and two weeks were analyzed by HPLC with
electrochemical detection after a treatment with sulfatase/beta-glucuronidase. Almost all of the
quercetin metabolites in the plasma were sulfate/glucuronide conjugates of quercetin and
isorhamnetin. More than 4.6% (w/w) of soybean oil in the diets significantly enhanced the
accumulation of quercetin metabolites in the plasma. Fish oil and beef tallow increased this to an
extent similar to that with soybean oil, and lecithin was more effective than the other three
lipids. Two emulsifiers, sodium caseinate and sucrose fatty acid ester, also showed an enhancing
effect on the accumulation of quercetin metabolites. These results indicate that co-ingested lipids
and emulsifiers could enhance the bioavailability of quercetin glucosides in onion.

PMID: 14730132 [PubMed - in process]


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