Road bike wise I like my 1984 Trek 660 with Suntour Superbe components the best because that component group was bombproof even after 160,000 miles without a failure it's still going strong, it's my second most comfortable bike to ride; but I like a bike when it's reliable, plus the bike and I have a lot of history together. BUT, I like the ride quality of my 2013 Lynskey better than any bike own or ever owned, so I'll have to put up with less reliability of the modern components made today to enjoy the ride quality of the Lynskey. The Lynskey even rides more comfortable than my touring bikes! something about titanium that no other frame material can do.
The crazy thing about all of this, if I had to get rid of all my bikes except one I would keep my 04 Mercian because it looks fantastic and it's more versatile than either the Trek or the Lynskey because I can tour with it, and the 32mm tires can do mild off roading, it's easier to find replacement parts then my old school touring bikes even though I use my one of my old school bikes exclusively for touring. Though it's not my favorite bike to ride for comfort nor dependability, (new school stuff won't last anywhere near as long as the old school stuff), it is the most versatile and I can get parts more readily.