Generally, I think most of the changes are reasonable.
I don't really like removal of car->pit telemetry and team/driver radio communication (might rob us of some interesting adaptable strategies, for instance to cater for changeable weather or out-of-position qualifying; such strategies might have been more widely used than in past years with the team now not being table to tinker much with the car between qualifying and race) but I'm not going to spew about it. Drivers would still be able to communicate basic info to the team, even if they have to resort to something as crude as pre-arranged hand gestures when passing the pits or when passing team spotters. Safety is another concern about radio communication, but presumably there'll still be radio between driver and race control.
I'm not all that keen on the spare care ban either, if it means the grids are smaller. Have to see how that one works out in practice (how drivers tackle qualifying, etc.).
Banning of driver aids (traction control, launch control, fully automatic gearboxes) is OK with me, even though I'm a geek and would probably be working on those aspects if I were in the industry. Raw skill and differences in driving style should become more apparent.
I'm not too fussed about the standardised rear wing either (although I'd prefer it if the regulations regarding number of elements, total area, maximum chord, etc., had just been tightened instead, leaving it up to the individual teams to come up with their own solutions). There are still
plenty of areas open for innovation... just don't standardise much more stuff!
The only changes I really,
really dislike are the extensions of the single engine rule to two events in 2005, and to six

events in 2006. Sheesh!

Even if you can start from the back of the grid if your engine detonated in the previous event, it just isn't reasonable to incur such a penalty for 35% of the season (assuming there are 17 races in 2006).