Gastroprotection by vitamin C

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Subject: Gastroprotection by vitamin C
From: [email hidden] (doe)
Date: 11/27/03 3:03 AM Eastern Standard Time
Message-id: <[email hidden]>

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Free oxygen radicals contribute to gastric mucosal damage induced by
acetylic-salicylic acid (ASA).

So, once again we prove that asprin irritates the stomach. Very revealing.

Thanks,

Dr. C PhD.

And......glutathione recycles Vitamin C 🙂))

doe <[email hidden]> wrote in message
news:[email hidden]...

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Biochem Biophys Res Commun. 2003 Dec 12;312(2):507-12. Related Articles,

Links

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Gastroprotection by vitamin C-a heme oxygenase-1-dependent mechanism?

Becker JC, Grosser N, Boknik P, Schroder H, Domschke W, Pohle T.

Department of Medicine B, University of Munster, Munster, Germany

Free oxygen radicals contribute to gastric mucosal damage induced by
acetylic-salicylic acid (ASA). Vitamin C has been shown to reduce gastric
toxicity of ASA in humans. We intended to assess the role of heme

oxygenase-1

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(HO-1) in this process by application of these substances to AGS and KATO

III

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cells. HO-1 expression was monitored by real-time RT-PCR, Western blot,

and HO

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activity measurement. HO-1 mRNA was significantly elevated by either ASA

or

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vitamin C in gastric epithelial cells, combination of both substances

further

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increased expression. HO-1 protein and enzyme activity rose in cells

exposed to

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vitamin C alone or combined with ASA, but not after stimulation with ASA

alone.

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In contrast to endothelia, in which ASA simultaneously induces HO-1 mRNA

and

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protein expression, gastric epithelial cells require vitamin C to

translate

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HO-1 mRNA into active protein, which then may exert gastroprotection by

its

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antioxidant and vasodilative properties.

PMID: 14637166 [PubMed - in process]

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