These studies seem to tell us the mode of action of glucosamine in arthritis is the SAME as the mode of action of indocin or indomethacine or .. aspirin .. or .. tagamet or .. metal binding. <<snip>> Glucosamine is a precursor to a molecule called a glycosaminoglycan-this molecule is used in the formation and repair of cartilage. Chondroitin is the most abundant glycosaminoglycan in cartilage and is responsible for the resiliency of cartilage. <<snip>> http://tinyurl.com/2be6h <<snip>> These outcomes confirm the antioxidant properties of GAGs (glycosaminoglycans) and further support the hypothesis that these molecules may function as metal chelators. <<snip>> http://tinyurl.com/25yzo Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
On 2004-03-07 15:57:06 -0500, [email protected] (doe) said: > These studies seem to tell us the mode of action of > glucosamine in arthritis is the SAME as the mode of action > of indocin or indomethacine or .. aspirin .. or .. tagamet > or .. metal binding. > > <<snip>> Glucosamine is a precursor to a molecule called a > glycosaminoglycan-this molecule is used in the formation > and repair of cartilage. Chondroitin is the most abundant > glycosaminoglycan in cartilage and is responsible for the > resiliency of cartilage. <<snip>> > > http://tinyurl.com/2be6h > > <<snip>> These outcomes confirm the antioxidant properties > of GAGs (glycosaminoglycans) and further support the > hypothesis that these molecules may function as metal > chelators. <<snip>> Eh? This is a four-year-old article, basically an opinion piece. And where was it published? I didn't think so.
>Subject: Re: glucosamine / metal chelator >From: anon [email protected] >Date: 3/7/2004 5:11 PM Mountain Standard Time >Message-id: <2004030719112650073%[email protected]> > >On 2004-03-07 15:57:06 -0500, [email protected] >(doe) said: > >> These studies seem to tell us the mode of action of >> glucosamine in >arthritis is >> the SAME as the mode of action of indocin or >> indomethacine or .. aspirin .. >or >> .. tagamet or .. metal binding. >> >> <<snip>> Glucosamine is a precursor to a molecule called >> a glycosaminoglycan-this molecule is used in the >> formation and repair of cartilage. Chondroitin is the >> most abundant glycosaminoglycan in cartilage and is >> responsible for the resiliency of cartilage. <<snip>> >> >> http://tinyurl.com/2be6h >> >> <<snip>> These outcomes confirm the antioxidant >> properties of GAGs >(glycosaminoglycans) >> and further support the hypothesis that these molecules >> may function as >metal >> chelators. <<snip>> > > >Eh? This is a four-year-old article, basically an opinion >piece. And where was it published? I didn't think so. Published in '03 .. Glycoconj J. 2003 Feb;20(2):133-41. Links Glycosaminoglycans reduce oxidative damage induced by copper (Cu(+2)), iron (Fe(+2)) and hydrogen peroxide (H(2)O(2)) in human fibroblast cultures. Campo GM, D'Ascola A, Avenoso A, Campo S, Ferlazzo AM, Micali C, Zanghi L, Calatroni A. Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, Policlinico Universitario, 98125 Messina, Italy. [email protected] Acid glycosaminoglycans (GAGs) antioxidant activity was assessed in a fibroblast culture system by evaluating reduction of oxidative system-induced damage.Three different methods to induce oxidative stress in human skin fibroblast cultures were used. In the first protocol cells were treated with CuSO(4) plus ascorbate. In the second experiment fibroblasts were exposed to FeSO(4) plus ascorbate. In the third system H(2)O(2) was utilised.The exposition of fibroblasts to each one of the three oxidant systems caused inhibition of cell growth and cell death, increase of lipid peroxidation evaluated by the analysis of malondialdehyde (MDA), decrease of reduced glutathione (GSH) and superoxide dismutase (SOD) levels, and rise of lactate dehydrogenase activity (LDH).The treatment with commercial GAGs at different doses showed beneficial effects in all oxidative models. Hyaluronic acid (HA) and chondroitin-4-sulphate (C4S) exhibited the highest protection. However, the cells exposed to CuSO(4) plus ascorbate and FeSO(4) plus ascorbate were better protected by GAGs compared to those exposed to H(2)O(2).These outcomes confirm the antioxidant properties of GAGs and further support the hypothesis that these molecules may function as metal chelators. Published in 2004. PMID: 15001845 [PubMed - in process] ------------------------------------------------------------ -------------- ------ Who loves ya. Tom Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
