excerpt Unprecedented’ Researchers in the United States turned this particular strain of good cholesterol into an experimental drug and gave it to 36 Americans with severe heart disease, people whose arteries were clogged with plaque. Eleven others received a placebo. "This is the first time we've ever given good cholesterol as a therapeutic agent," said Dr. Steven Nissen of the Cleveland Clinic Foundation and lead author of the study. Those given the placebo saw little change in their condition. But for those given the experimental drug, the result was dramatic. "It was unprecedented," said Dr. Daniel Rader of the University of Pennsylvania School of Medicine, who reviewed the study. "This study shows that plaque regression occurred much faster and to a greater extent than we've ever seen before." After just five weekly infusions, researchers saw, on average, a 4 percent reduction in the amount of plaque on artery walls. "Regression of 4 percent, while that might not seem like much, actually represents several years worth of plaque buildup in the coronary arteries," Rader told ABCNEWS. It made a big difference to 51-year-old John Pierce, of Waterville, Ohio, whose arteries were severely clogged. "I feel like my old self again," said Pierce. "There's no pain in the chest, there's no tightness in the chest, there's no shortness of breath." ... Depressed? Try Fish Oil Researchers are finding that fatty acids found in fish oil have the same result in treating depression as traditional psychiatric medications such as Prozac.