Bull Exp Biol Med. 2003 Oct;136(4):362-5. Links
Oxidative modification of erythrocyte membranes in the acute stage of severe craniocerebral trauma
and its correction with clonidine.
Karmen NB.
Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences, Pushchino.
[email hidden]
Acute posttraumatic stage of severe craniocerebral trauma was characterized by considerable
activation of lipid peroxidation and exhaustion of the antioxidant enzyme system. Oxidative
modification of membranes was accompanied by structural and functional changes. The antihypoxic
effect of clonidine was realized directly in the lipid phase of membranes. This preparation
inhibited lipid peroxidation and activated antioxidant enzymes, which prevented the development of
structural and functional changes in membranes.
PMID: 14714083 [PubMed - in process]
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