Hepatocarcinogenesis / phytic acid

Discussion in 'Food and nutrition' started by [email protected], Mar 27, 2005.

  1. Asian Pac J Cancer Prev. 2005 Jan-Mar;6(1):41-7. Related Articles,
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    Dietary Administration of Inositol and/or Inositol-6-phosphate Prevents
    Chemically-induced Rat Hepatocarcinogenesis.

    Lee HJ, Lee SA, Choi H.

    Department of Food and Nutrition, Seoul National University, Seoul
    151-742, Korea. [email protected].

    Chemoprevention is considered a rational strategy for dietary
    approaches to prevention of cancer. Multiple lines of evidence suggest
    that many of our dietary principles are able to intervene in the
    multistage carcinogenesis process and phytic acid (inositol
    hexaphosphate, IP6), a phytochemical present in a variety of plant
    species, has been shown to prevent various cancers, including those of
    the mammary gland, colon and liver. However, the mechanism of
    chemoprevention by IP6 has not been fully elucidated. In the present
    study, we examined the effects of inositol and/or IP6 supplementation
    on rat hepatocarcinogenesis initiated by diethylnitrosamine (DEN) and
    promoted by partial hepatectomy (PH). Supplementation with either
    inositol or IP6, or their combination, starting one week prior to
    administration of DEN, resulted in a significant decrease in both the
    area and the number of placental glutathione S-transferase positive
    (GST-P+) foci, a preneoplastic marker for DEN-initiated
    hepatocarcinogenesis. The administration of inositol and/or IP6 in
    drinking water caused marked enhancement in the glutathione
    S-transferase (GST) activity. In addition, the production of
    thiobarbituric acid reactive substances and the catalase activity were
    significantly reduced in rats supplemented with inositol and /or IP6.
    Based on these findings, it is likely that the chemopreventive effects
    of inositol and/or IP6 on rat hepatocarcinogenesis initiated by DEN and
    promoted by PH are associated with induction of GST activity and
    suppression of lipid peroxidation.

    PMID: 15780031 [PubMed - in process]

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