Herbal Preparation May Prevent RTI in Children

Discussion in 'Health and medical' started by tobyjones, Mar 12, 2004.

  1. tobyjones

    tobyjones Guest

    Herbal Preparation May Prevent Respiratory Tract Infection
    in Children Yael Waknine

    March 2, 2004 — An herbal preparation containing echinacea,
    propolis, and vitamin C may be effective in preventive
    respiratory tract infections in children, according to
    results of a randomized, double-blind, placebo-controlled
    multicenter study published in the March issue of the
    Archives of Pediatric and Adolescent Medicine.

    The herbal preparation (Chizukit) is made up of 50 mg/mL of
    echinacea, 50
    mg/mL of propolis, and 10 mg/mL of vitamin C. Echinacea
    is thought to have cytokine-modulating, macrophage,
    and natural killer cell activity, according to Herman
    A. Cohen, MD, and colleagues, from the Pediatric and
    Adolescent Ambulatory Community Clinic in Petach
    Tikva, Israel.

    Propolis has been shown to have antimicrobial, anticancer,
    and general anti-inflammatory effects, as well as some
    antiviral effect on herpes simplex virus type 1 and the
    influenza virus. Vitamin C is thought to increase
    proliferative responses of T lymphocytes in vitro, and to
    induce production of interferon in cell culture. Because
    concentrations of vitamin C are up to 100 times greater in
    phagocytes and lymphocytes than in plasma, vitamin C may
    have a physiologic role in these immune system cells,
    according to the authors.

    [snip]

    "This decrease in upper respiratory tract infections in
    young children would have significant economic and social
    ramifications," comments Shilpa Sangvai, MD, from the
    Children's Hospital of Pittsburgh in Pennsylvania, in an
    accompanying Journal Club report."

    [snip]

    Further info at link below.

    Arch Pediatr Adolesc Med. 2004;158:217-221, 222-224 Reviewed
    by Gary D. Vogin, MD Yael Waknine is a freelance writer for
    Medscape. www.medscape.com/viewarticle/470840?mpid=25713

    ----------

    Arch Pediatr Adolesc Med. 2004 Mar;158(3):217-21.

    Effectiveness of an herbal preparation containing echinacea,
    propolis, and vitamin C in preventing respiratory tract
    infections in children: a randomized, double-blind, placebo-
    controlled, multicenter study.

    Cohen HA, Varsano I, Kahan E, Sarrell EM, Uziel Y. Pediatric
    and Adolescent Ambulatory Community Clinic, Petach Tikva,
    Israel. [email protected]

    OBJECTIVE: To evaluate the effectiveness and safety of a
    preparation containing echinacea, propolis, and vitamin C in
    the prevention of respiratory tract infections in children
    during a 12-week winter period.

    DESIGN: Randomized, double-blind, placebo-controlled study.

    SUBJECTS: Four hundred thirty children, aged 1 to 5 years,
    were randomized to an herbal extract preparation (n = 215)
    or a placebo elixir (n = 215).

    INTERVENTION: Administration of an herbal preparation
    (Chizukit) containing 50 mg/mL of echinacea, 50 mg/mL of
    propolis, and 10 mg/mL of vitamin C, or placebo (5.0 mL and
    7.5 mL twice daily for ages 1 to 3 years and 4 to 5 years,
    respectively) for 12 weeks.

    RESULTS: Significant mean +/- SD reductions of illnesses
    were seen in the Chizukit group in the number of illness
    episodes, 138 vs 308 (55% reduction); number of episodes per
    child, 0.9 +/- 1.1 vs 1.8 +/- 1.3 (50% reduction, P<.001);
    and number of days with fever per child, 2.1 +/- 2.9 vs 5.4
    +/- 4.4) (62% reduction, P<.001). The total number of
    illness days and duration of individual episodes were also
    significantly lower in the Chizukit group. Adverse drug
    reactions were rare, mild, and transient.

    CONCLUSION: A preventive effect of a product containing
    echinacea, propolis, and vitamin C on the incidence of
    respiratory tract infections was observed.

    http://tinyurl.com/2975r http://www.ncbi.nlm.nih.gov/entrez-
    /query.fcgi?cmd=Retrieve&db=pubmed&dopt=A
    bstract&list_uids=14993078
     
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