HIV and TB infections / iron

Discussion in 'Food and nutrition' started by [email protected], Apr 8, 2006.

  1. Iron and infection: effects of host iron status and the iron-regulatory
    genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in
    tuberculosis and HIV.
    McDermid JM, Prentice AM
    Clin Sci (Lond). 2006 May ; 110(5): 503-24

    There are many lines of evidence illustrating that iron plays a pivotal
    role in modulating the battle for survival between mammalian hosts and
    their pathogens. Each displays considerable genetic investment in a
    wide range of mechanisms for acquiring and maintaining iron. These
    competitive mechanisms are highly complex, existing within an
    interacting matrix of absorption, transport, storage and detoxification
    systems, each of which are iron-responsive and thus able to adapt to
    the different phases of infection. Considerable genetic polymorphism in
    some of these systems, with signals of geographic selection in the
    hosts, and niche selection in the pathogens, indicates that they are
    critical for species survival. In this review we briefly summarize the
    role of iron in host immune function before reviewing the available
    evidence that iron modulates susceptibility and disease outcomes in HIV
    and TB (tuberculosis). We then examine the putative role of
    iron-related host genes by focussing on two candidate genes,
    haptoglobin and NRAMP1, for which there are common polymorphic variants
    in humans with strong evidence of functionally distinct biochemical
    phenotypes that would be predicted to influence the course of HIV and
    TB infections. Finally, we examine the limited evidence so far
    available that nutrient-gene interactions are likely to influence the
    way in which gene variants can protect against infection. We conclude
    that there is a wealth of evidence associating alterations in iron
    balance and in iron-regulatory systems with disease progression, but
    that many issues related to the direction of causality, mechanisms of
    action and sensitivity to pharmacological intervention remain to be
    elucidated. Since iron is probably the most widely prescribed compound
    throughout the world, used in both preventative and treatment regimens,
    a deeper understanding of the host-pathogen interactions relating to
    iron constitutes an important area for both basic and clinical
    research.

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    Tom


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    DEAD PEOPLE WALKING
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