"This is impossible. It says absolutely nothing about calories. Calories are the only factor that influences weight gain and weight loss. This goes against everthing we know about obesity and the laws of thermodynamics." Every time you assert something about the topic of calories you end up with another hole in your foot, you still don't grasp the basics of the science involved. The article doesn't bother to review what is basic and assumed knowledge generally at hand. Hormones are part of the feedback and feedforward system by which the body in part allows various organs to communicate. In the subject of the article one of these is identified,ie. as we eat its level changes which signals the brain that we have eaten enough. When this happens within the normal parameter of calories consumed there is no weight gain from excess calories being stored. In some people the hormone signaling is out of wack and the "enough" signal either comes too late or at a level that is not effective to easily stop caloric intake. This is not the only hormone with this effect and various nutrients are better at evoking them in appetite control even to the point of even feeling hungary in the first place.