Hormone Key to Keeping Weight Off



"This is impossible. It says absolutely nothing about calories. Calories
are the only factor that influences weight gain and weight loss. This goes
against everthing we know about obesity and the laws of thermodynamics."

Every time you assert something about the topic of calories you end up
with another hole in your foot, you still don't grasp the basics of the
science involved. The article doesn't bother to review what is basic and
assumed knowledge generally at hand. Hormones are part of the feedback
and feedforward system by which the body in part allows various organs to
communicate. In the subject of the article one of these is identified,ie.
as we eat its level changes which signals the brain that we have eaten
enough.

When this happens within the normal parameter of calories consumed there
is no weight gain from excess calories being stored. In some people the
hormone signaling is out of wack and the "enough" signal either comes too
late or at a level that is not effective to easily stop caloric intake.
This is not the only hormone with this effect and various nutrients are
better at evoking them in appetite control even to the point of even
feeling hungary in the first place.
 
T

TC

Guest
http://www.forbes.com/lifestyle/health/feeds/hscout/2005/12/01/hscout529360.html

Hormone Key to Keeping Weight Off
-- Robert Preidt


THURSDAY, Dec. 1 (HealthDay News) -- A new study offers insight into
why it's easier to lose weight than to keep it off for good.

Body weight is regulated by metabolic, neuroendocrine, and autonomic
systems, which work together to restore fat mass in people who've lost
weight, the study authors concluded. That's because the body interprets
reductions in weight as a deficiency in the hormone leptin.

These mechanisms explain why more than 85 percent of obese people
who've lost weight eventually regain those pounds, the Columbia
University researchers said.

They tested this theory by giving "replacement" doses of leptin to
obese people and to lean people who'd just lost weight. The leptin
doses reversed most of the metabolic, neuroendocrine and autonomic
changes that occur in an effort to counter reduced body weight.

The study appears in the Dec. 1 issue of the Journal of Clinical
Investigation.

The findings suggest that drugs that target the leptin signaling
pathway may help prevent people from regaining weight after they've
lost it, the scientists said.

A study published in November found that in obese rats, the receptor
for leptin -- which makes fat burn up -- disappears from fat cells.
This means that leptin can't act on the fat cells, the University of
Texas Southwestern Medical Center at Dallas researchers said.

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This is impossible. It says absolutely nothing about calories. Calories
are the only factor that influences weight gain and weight loss. This
goes against everthing we know about obesity and the laws of
thermodynamics.

TC