Hostile men face heightened heart attack risk
ANI The Times of India Thursday, July 31, 2003
Washington - A new research in psychosomatic medicine has revealed that healthy but hostile and
depressive men face a heightened risk of heart attack.
"The new findings suggest the possibility that mild to moderate levels of depression symptoms
combined with feelings of hostility in men may raise their levels of a protein that is associated
with clogged arteries and a greater risk of heart attack," said to Edward C Suarez, of Duke
University Medical Center.
"Although studies have shown that hostility and depressive symptoms are associated with greater risk
of heart disease, the reasons for these associations are not well understood. It is increasingly
apparent, however, that inflammation in the bloodstream is linked with heart disease," Suarez noted.
Previous studies indicate that the protein, called IL-6, is at least a marker of inflammation, and
may even be involved in the inflammatory processes that cause artery thickening and buildup.
However, researchers know little about IL-6's relation to psychological risk factors.
Suarez examined the link between depression and hostility and IL-6 levels in 90 healthy, non-smoking
men aged between 18 to 45.
After giving a blood sample, the participants answered two questionnaires to determine their level
of depressive symptoms and hostility.
Men who scored highest on both questionnaires, indicating increased symptoms of depression and
higher levels of hostility, had IL-6 levels that were two to five times higher than men who scored
low on both questionnaires or scored high on only one questionnaire.
The association between the psychological factors and IL- 6 held steady even after accounting for
other factors associated with IL-6, such as age, body weight, cholesterol levels and blood pressure.
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