How fatty diet may cause diabetes IN MICE

Discussion in 'Food and nutrition' started by Ignoramus24987, Dec 30, 2005.

  1. Applies to mice, but interesting.

    It is not inconsistent with how both low fat and low carb diets may


    How fatty diet may cause diabetes
    Researchers say they have discovered how a high-fat Western-style diet
    may increase the risk of type 2 diabetes.

    A team at the University of California, San Diego found eating lots of
    fat blocks production of an enzyme key to the production of the
    hormone insulin.

    The study was carried out on mice, but the researchers hope their
    findings will lead to new ways to treat and prevent the condition in

    Details are published in the journal Cell.

    The number of people with diabetes has soared to over two million in
    the UK.

    Of these, the vast majority - about 1.7 million - have the type 2
    diabetes, which is associated with obesity.

    The San Diego team found insulin production can be disrupted by
    knocking out a single gene which controls production of a key enzyme
    called GnT-4a.

    If our findings can be applied to humans, they should give us
    important insights into how type 2 diabetes may be prevented and
    Dr Jamey Marth

    They then showed that a high-fat diet suppresses activity of the same
    key gene.

    Insufficient levels of the enzyme were found to compromise the ability
    of beta cells in the pancreas to produce insulin in response to rising
    levels of glucose in the blood, for instance after a meal.

    Failure to control glucose levels eventually leads to full-blown type
    2 diabetes.

    The researchers suggest people with an inherited predisposition to
    type 2 diabetes might have variations in the GnT-4a gene.

    Molecular pathway

    Their study showed that when a beta cell lacks sufficient levels of
    GnT-4a it is unable to absorb glucose across its outer membrane in the
    usual way.

    A direct role in the genetic predisposition to diabetes in man is
    Professor Andrew Hattersley

    Thus it becomes insensitive to rising levels of the sugar, and fails
    to secrete insulin in response.

    Researcher Dr Jamey Marth said: "If you could somehow stimulate
    production of this enzyme, you might be able to render animals, and
    perhaps humans, resistant to high-fat diet-induced diabetes.

    "If our findings can be applied to humans, they should give us
    important insights into how type 2 diabetes may be prevented and

    Andrew Hattersley, Professor of Molecular Medicine, Peninsula Medical
    School, Exeter, told the BBC News website: "Understanding why people
    who are obese are more likely to develop diabetes is very important
    and this research describes a new potential link.

    "However, it is uncertain if these mouse models are directly
    applicable to man.

    "In man there is a complex interaction between genetic susceptibility
    and environmental influence in type 2 diabetes and it is likely that
    there will be considerable variation in the causes of type 2 diabetes
    throughout the world.

    "A direct role in the genetic predisposition to diabetes in man is

    A spokesman for the charity Diabetes UK said: "This is certainly a
    very interesting piece of research.

    "One thing we do know is that the main factor driving type 2 diabetes
    is lifestyle; diet and lack of exercise.

    "If we could pinpoint what's behind the diet element that would be a
    significant breakthrough."

    Story from BBC NEWS:

    Published: 2005/12/29 00:18:03 GMT


  2. Pete Romfh

    Pete Romfh Guest

    While this is certainly a valid point to consider I'm not sure if I
    really CARE if the mice around my house are obese OR have diabetes. And
    I'm NOT testing their damn blood for them either.
    They'll have to test their own little selves. =;)

    I'm feeling a bit flippant this morning as I recover from two days of
    being "under the weather".
    But I'll be fine in a day or so.

    Pete Romfh