Hypertension / liver oxidative stress / iron chelators

Discussion in 'Food and nutrition' started by [email protected], Nov 21, 2005.

  1. <<snip>>
    Iron seems to be an inductor of liver oxidative stress and responsible
    for the persistent oxidative stress, most likely through secondary
    free-radical release.
    <<snip>>

    Evolution of liver antioxidant status and iron implication during the
    development of deoxycorticosterone-saline hypertension in rats.
    Elhaïmeur F, Nicod L, Courderot-Masuyer C, Robin S, Guyon C, Bouhaddi
    M, Regnard J, Richert L, Berthelot A
    Biol Trace Elem Res. 2005 Dec ; 107(3): 263-76

    Hypertension is known to be associated with an oxidative stress
    resulting from an imbalance of antioxidant defense mechanisms in
    various tissues. The purpose of this study was to investigate the
    relationship between the increase of arterial blood pressure, measured
    during the gradual development of experimental hypertension in
    deoxycorticosterone (DOCA)-salt-treated rats, and an early imbalance of
    liver antioxidant status. The levels of liver oxidant/antioxidant
    markers and iron were studied during the induction of hypertension in
    3-, 6-, and 8-wk DOCA-salt-treated Sprague-Dawley rats. Hepatic
    antioxidant defenses were decreased as early as 3 wk of hypertensive
    treatment: the decrease of peroxidase-reductase-transferase and
    catalase activities was associated with a significant increase of
    thiobarbituric acid reactive substances (TBARS) levels. Liver oxidative
    stress increased until 6 wk and remained stable at 8 wk of DOCA-salt
    treatment. Concurrently, liver iron levels were increased at 6 wk and
    returned to normal values after 8 wk of hypertensive treatment. Iron
    seems to be an inductor of liver oxidative stress and responsible for
    the persistent oxidative stress, most likely through secondary
    free-radical release. Thus, our data (1) confirm that hypertension in
    DOCA-salt-treated rats might be a free-radical-dependent disease where
    hepatic oxidant/antioxidant imbalance is obviously involved from the
    beginning of blood pressure elevation and (2) suggest that the use of
    suitable iron chelators might reverse liver oxidative stress associated
    with the increase of blood pressure.

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