INCREASED IRON / asthma



D

Doe

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These observations suggest that increased Fe and decreased Se concentrations in patients with
childhood asthma may be responsible for the oxidant/antioxidant imbalance.
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Biol Trace Elem Res. 2004 Jan; 97(1): 31-42. Related Articles, Links

Alterations in Plasma Essential Trace Elements Selenium, Manganese, Zinc, Copper, and Iron
Concentrations and the Possible Role of these Elements on Oxidative Status in Patients with
Childhood Asthma.

Kocyigit A, Armutcu F, Gurel A, Ermis B.

Department of Biochemistry, Medical Faculty, Harran University, Sanliurfa, Turkey.

The aim of the present study is to evaluate the status of plasma essential trace element selenium
(Se), manganese (Mn), copper (Cu), zinc (Zn), and iron (Fe) concentrations and the effect of these
elements on oxidative status in patients with childhood asthma. Plasma Se, Mn, Cu, and Zn
concentrations were determined by atomic absorption spectrophotometry (AAS) and Fe concentrations,
malondialdehyde (MDA), and total antioxidant capacity (TAC) were determined by the colorimetric
method. The plasma MDA/TAC ratio was calculated as an index of oxidative status. Plasma albumin
levels were measured to determine nutritional status. Plasma Fe concentrations, MDA levels and the
MDA/TAC ratio were significantly higher (p<0.001, p<0.001, and p<0.01, respectively) and Se and Mn
concentrations and TAC were lower (p<0.01, p<0.05, and p<0.01, respectively) in patients when
compared to the healthy subjects. Plasma Zn, Cu, and albumin levels were not found to be
significantly different in patients and controls
(p>.05). There were positive relationships between plasma MDA and Fe (r=0.545, p<0.001) and TAC and
Se (r= 0.485, p<0.021), and a negative correlation between TAC and MDA values (r= -0.337,
p<0.031) in patients with childhood asthma. However, there was no correlation between these trace
elements and albumin content in patient groups. These observations suggest that increased Fe and
decreased Se concentrations in patients with childhood asthma may be responsible for the
oxidant/antioxidant imbalance.

PMID: 14742898 [PubMed - as supplied by publisher]

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