Influenza vaccination reduces cardiac and stroke deaths and events


Matti Narkia

Several studies suggest that influenza vaccination is associated with a reduction in incidence of
sudden cardiac death, acute myocardial infarction, and ischemic stroke.

A news report about the latest study:

Flu Shots Reduce Deaths After Heart Attack Fri 23 January, 2004


1: Gurfinkel EP, Leon de la Fuente R, Mendiz O, Mautner B. Flu vaccination in acute coronary
syndromes and planned percutaneous coronary interventions (FLUVACS) Study. Eur Heart J. 2004
Jan;25(1):25-31. PMID: 14683739 [PubMed - in process] <URL:

2: Leon de la Fuente R, Gurfinkel EP, Toledo D, Mautner B; Grupo de Estudio FLUVACS. [Flu
vaccination in patients with acute coronary syndromes: treatment benefit in prespecified
subgroups] Rev Esp Cardiol. 2003 Oct;56(10):949-54. Spanish. PMID: 14563288 [PubMed - indexed

3: Nichol KL, Nordin J, Mullooly J, Lask R, Fillbrandt K, Iwane M. Influenza vaccination and
reduction in hospitalizations for cardiac disease and stroke among the elderly. N Engl J Med.
2003 Apr 3;348(14):1322-32. PMID: 12672859 [PubMed - indexed for MEDLINE]

4: Meyers DG. Myocardial infarction, stroke, and sudden cardiac death may be prevented by
influenza vaccination. Curr Atheroscler Rep. 2003 Mar;5(2):146-9. Review. PMID: 12573201
[PubMed - indexed for MEDLINE] <URL:

5: Naghavi M, Wyde P, Litovsky S, Madjid M, Akhtar A, Naguib S, Siadaty MS, Sanati S, Casscells W.
Influenza infection exerts prominent inflammatory and thrombotic effects on the atherosclerotic
plaques of apolipoprotein E-deficient mice. Circulation. 2003 Feb 11;107(5):762-8. PMID:
12578882 [PubMed - indexed for MEDLINE] <URL:

6: Meyers DG. Could influenza vaccination prevent myocardial infarction, stroke and sudden
cardiac death? Am J Cardiovasc Drugs. 2003;3(4):241-4. PMID: 14728076 [PubMed - in process]

7: Jackson LA, Yu O, Heckbert SR, Psaty BM, Malais D, Barlow WE, Thompson WW; Vaccine Safety
Datalink Study Group. Influenza vaccination is not associated with a reduction in the risk of
recurrent coronary events. Am J Epidemiol. 2002 Oct 1;156(7):634-40. PMID: 12244032 [PubMed -
indexed for MEDLINE] <URL:

8: Gurfinkel E, Mautner B. [Secondary prevention of coronary artery disease. Flu vaccinations and
new evidence of the role of infection in acute coronary syndromes.] Rev Esp Cardiol. 2002 Oct;55(10):1009-
12. Spanish. PMID: 12383382 [PubMed - indexed for MEDLINE] <URL:

9: Gurfinkel EP, de la Fuente RL, Mendiz O, Mautner B. Influenza vaccine pilot study in acute
coronary syndromes and planned percutaneous coronary interventions: the FLU Vaccination Acute
Coronary Syndromes (FLUVACS) Study. Circulation. 2002 May 7;105(18):2143-7. PMID: 11994246
[PubMed - indexed for MEDLINE] <URL:

10: Lavallee P, Perchaud V, Gautier-Bertrand M, Grabli D, Amarenco P. Association between influenza
vaccination and reduced risk of brain infarction. Stroke. 2002 Feb;33(2):513-8. Erratum in:
Stroke 2002 Apr;33(4):1171. PMID: 11823662 [PubMed - indexed for MEDLINE] <URL:http://www.ncbi->

11: Naghavi M, Barlas Z, Siadaty S, Naguib S, Madjid M, Casscells W. Association of influenza
vaccination and reduced risk of recurrent myocardial infarction. Circulation. 2000 Dec 19;102(25):3039-
45. PMID: 11120692 [PubMed - indexed for MEDLINE]

Matti Narkia