Insulin Resistance



S

Sleepyman

Guest
Wondering about Insulin Resistance. As I know there is no specific insulin resistance test, do we
know if it is a semi-constant level, that can be brought down slowly, or is it more similar to Bg
levels, in that it can change rapidly?

Sleepy

-----------------
Eskimo/Inuit up!
-----------------
T2- 3/14/01
 
O

Ozgirl

Guest
"Sleepyman" <[email protected]> wrote in message
news:[email protected]...
> Wondering about Insulin Resistance. As I know there
is no specific insulin
> resistance test, do we know if it is a semi-constant
level, that can be
> brought down slowly, or is it more similar to Bg
levels, in that it can
> change rapidly?

Insulin resistance is tied in with fat. The more fat tissue you have the more likely you are to have
insulin resistance. It wouldn't change rapidly, even with dieting, as it takes a while for someone
to go from obesity to normal weight levels (or making more muscle and reducing the fat tissue).
Reducing insulin resistance can happen with diet alone but most doctors prefer to give an insulin
resistance drug to type 2's like Metformin as well as advise weight loss. Building muscle mass is a
big help also.

Insulin resistance does not mean a type 2 can't control their diabetes. Many obese type 2's control
with very low carb. But losing the fat tissue and gaining muscle would help enormously, allow a bit
more leeway re the amount of carbs a type 2 could eat every meal. Not all overweight, underexercised
people progress to diabetes, there is still a genetic pre disposition (unless there has been a
breakthrough I haven't heard about).

So in a nutshell, keep weight close to normal and keep active (building muscle helps) and you may
never get insulin resistance or if you have it already you can control the type 2 much easier.
 
C

Charly Coughran

Guest
Sleepyman <[email protected]> wrote in
news:[email protected]:

> Wondering about Insulin Resistance. As I know there is no specific insulin resistance test, do we
> know if it is a semi-constant level, that can be brought down slowly, or is it more similar to Bg
> levels, in that it can change rapidly?

There are actually a couple of methods for measuring insulin resistance, but they are usually
reserved for research settings.

As there are a number of mechanisms that cause insulin resistance, some understood fairly well
and some not at all well, and there are a number of time scales involved. Some are reversible
and some not.

Three of the most common mechanisms for increasing insulin resistance are aging, weight gain, and
sedentary life style. While these aspects are clearly related, it appears that they function to some
degree independently.

It is, of course, fairly difficult to do much about aging. Removing excess weight, or more properly
body fat ratio, seems to have a range of difficulty in the population. None-the-less it is clear
that reducing excess weight will reduce insulin resistance. Sometimes a relatively small weight loss
will produce noticeable results. The time scale is, naturally, the time scale of the weight loss.

Exercise effects insulin resistance on several time scales. There is an immediate effect during
exercise as insulin independent glucose disposal pathways are opened up. As exercise becomes
regular, other insulin resistance reductions appear and persist for various periods from a few days
to a few weeks. It may take a few days to a few weeks to begin to see these results.
 
O

Oldal4865

Guest
Sleepyman wrote in message <[email protected]>...
>Wondering about Insulin Resistance. As I know there is no specific insulin resistance test, do we
>know if it is a semi-constant level, that can be brought down slowly, or is it more similar to Bg
>levels, in that it can change rapidly?
>
>Sleepy
>

There are a variety of Insulin Resistance Tests. Some are reserved for the Research Docs only

(e.g. Euglycemic Insulin Clamp or Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT)

One test which your doc can run is the HOMA-R test. One measures fasting blood sugar and fasting
insulin level simultaneously.

The product of the the values is a measure of Insulin Resistance.

Much, much, more than a normal person would want to know about HOMA can be found at:

http://www.medforum.nl/idm/vascular_dysfunction_precedes____.htm

http://care.diabetesjournals.org/cgi/reprint/23/4/449.pdf

The QUICKI test is mathematically equivalent to the HOMA test

Of course, that measures your Insulin Resistance "that morning"

I find that heavy exercise can affect my insulin injection requirements for 24 hours. Since I am
chubby ( let us avoid the "O" word) I presume that I am tracking effects on exercise on Insulin
Resistance.

High blood sugars can (will??) produce temporary Insulin Resistance.

Regards
Old Al
 
M

markd

Guest
One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where a
value of < 3 is taken as a good measure of resistence.

>Wondering about Insulin Resistance. As I know there is no specific insulin resistance test, do we
>know if it is a semi-constant level, that can be brought down slowly, or is it more similar to Bg
>levels, in that it can change rapidly?
>
>Sleepy
>
>-----------------
>Eskimo/Inuit up!
>-----------------
>T2- 3/14/01
 
P

Priscilla Ballo

Guest
In article <[email protected]>,
[email protected] wrote:

> One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where
> a value of < 3 is taken as a good measure of resistence.

You sure that's not greater than 3 rather than less than 3? A tri/HDL ratio of less than or equal to
2.0 is ideal.

Priscilla
 
H

Herman Rubin

Guest
In article <[email protected]>,
<[email protected]> wrote:

>One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where
>a value of < 3 is taken as a good measure of resistence.

This seems strange, as high triglycerides are considered bad and high HDL is considered good.
--
This address is for information only. I do not claim that these views are those of the Statistics
Department or of Purdue University. Herman Rubin, Department of Statistics, Purdue University
[email protected] Phone: (765)494-6054 FAX: (765)494-0558
 
O

Oldal4865

Guest
Priscilla Ballou wrote in message ...
>In article <[email protected]>, [email protected] wrote:
>
>> One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl,
>> where a value of < 3 is taken as a good measure of resistence.
>
>You sure that's not greater than 3 rather than less than 3? A tri/HDL ratio of less than or equal
>to 2.0 is ideal.
>
>Priscilla

That one came up a while back. The 3.0 is a conservative estimate of "too high"; it identifies
the abnormal conditions brought about by elevated Insulin Resistance.

When you think about it, a conservative estimate of abnormal really shouldn't be that close to
"ideal" lest you end up with a slew of false negatives.

Regards
Old Al
 
K

K'Neh'A'Iw

Guest
Herman Rubin wrote:

> In article <[email protected]>, <[email protected]> wrote:
>
>
>>One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where
>>a value of < 3 is taken as a good measure of resistence.
>
>
> This seems strange, as high triglycerides are considered bad and high HDL is considered good.

The lower the ratio the better;

TG 200/ HDL 35 ration is 6; these are common diabetic values.

TC 100/ HDL 50 ration is 2; these are cited as target values

--
K'neH'a'Iw

Uncloaking, Shields up.
 
M

markd

Guest
I don't follow your question. The info I have seen is < 3, which is also what = to or < 2 would
encompass. That number is using the US unit of measure, the number outside of the US is indeed a
lower number for that measureing scale.

> One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where
> a value of < 3 is taken as a good measure of resistence.

You sure that's not greater than 3 rather than less than 3? A tri/HDL ratio of less than or equal to
2.0 is ideal.
 
M

markd

Guest
You are correct, but in those with high insulin resistence the ratio is over 3, trig and hdl are not
directly related. A trig of 300 and hdl of 50 has a ratio of 6. The numbers above are not unusual in
a diabetic where trigs often sore even with a good hdl; such as the 50 in the example. High
resistence leads to high trigs, which can in time lead to poor hdl numbers also, the trigs don't
directly create the hdl level.

>One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl, where
>a value of < 3 is taken as a good measure of resistence.

This seems strange, as high triglycerides are considered bad and high HDL is considered good.
 
P

Priscilla H Bal

Guest
[email protected] quoth:
>I don't follow your question. The info I have seen is < 3, which is also what = to or < 2 would
>encompass.

No, =< 2 would be included in <3. It wouldn't encompass it. (The smaller cannot encompass
the larger.)

> That number is using the US unit of measure, the number outside of the US is indeed a lower number
> for that measureing scale.

I think the confusion is in the way you worded it.

You said that less than 3 was "a good measure of resistence." Do you mean that it's a good value in
terms of resistence, or it's an effective measure of resistence? I read it as the latter, which
seems backwards to me. A higher value would indicate greater resistence. 3 is a lower value and
would not be so clearly indicating resistence.

>> One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl,
>> where a value of < 3 is taken as a good measure of resistence.

>You sure that's not greater than 3 rather than less than 3? A tri/HDL ratio of less than or equal
>to 2.0 is ideal.

Priscilla
 
H

Herman Rubin

Guest
In article <[email protected]>,
K'neH'a'Iw <K'neH'a'[email protected]> wrote:
>Herman Rubin wrote:

>> In article <[email protected]>, <[email protected]> wrote:

>>>One rule of thumb is the ratio of lipid blood values. In particular the ratio of trig / hdl,
>>>where a value of < 3 is taken as a good measure of resistence.

>> This seems strange, as high triglycerides are considered bad and high HDL is considered good.

>The lower the ratio the better;

>TG 200/ HDL 35 ration is 6; these are common diabetic values.

>TC 100/ HDL 50 ration is 2; these are cited as target values

I definitely have insulin resistance. However, my last ratio was TG 80 / HDL 85. My previous ones
were not that good, but were still less than 2.
--
This address is for information only. I do not claim that these views are those of the Statistics
Department or of Purdue University. Herman Rubin, Department of Statistics, Purdue University
[email protected] Phone: (765)494-6054 FAX: (765)494-0558
 
K

K'Neh'A'Iw

Guest
Herman Rubin wrote:

>>The lower the ratio the better;
>
>
>>TG 200/ HDL 35 ration is 6; these are common diabetic values.
>
>
>>TC 100/ HDL 50 ration is 2; these are cited as target values
>
>
> I definitely have insulin resistance. However, my last ratio was TG 80 / HDL 85. My previous ones
> were not that good, but were still less than 2.

Mine are in that same range, but I don't know if I am insulin resistant or not. I assume I am
because I am T2.

--
K'neH'a'Iw

Uncloaking, Shields up.