Iron chelators with anti-malarial activity

Discussion in 'Food and nutrition' started by Doe, Dec 24, 2003.

  1. Doe

    Doe Guest

    Int J Biochem Cell Biol. 2004 Mar;36(3):401-7. Related Articles, Links

    Novel aroylhydrazone and thiosemicarbazone iron chelators with anti-malarial activity against chloroquine-
    resistant and -sensitive parasites.

    Walcourt A, Loyevsky M, Lovejoy DB, Gordeuk VR, Richardson DR.

    Center for Sickle Cell Disease, Howard University, 2121 Georgia Ave, 20060, Washington, DC, USA

    Iron (Fe) is crucial for cellular proliferation, and Fe chelators have shown activity at preventing
    the growth of the malarial parasite in cell culture and in animal and human studies. We investigated
    the anti-malarial activity of novel aroylhydrazone and thiosemicarbazone Fe chelators that show high
    activity at inhibiting the growth of tumour cells in cell culture [Blood 100 (2002)
    666]. Experiments with the chelators were performed using the chloroquine-sensitive, 3D7, and chloroquine-
    resistant, 7G8, strains of Plasmodium falciparum in vitro. The new ligands were significantly
    more active in both strains than the Fe chelator in widespread clinical use, desferrioxamine
    (DFO). The most effective chelators examined were 2-hydroxy-1-naphthylaldehyde isonicotinoyl
    hydrazone and 2-hydroxy-1-naphthylaldehyde-4-phenyl-3-thiosemicarbazone. The anti-malarial
    activity correlates with anti-proliferative activity against neoplastic cells demonstrated in a
    previous study. Our studies suggest that this class of lipophilic chelators may have potential
    as useful agents for the treatment of malaria.

    PMID: 14687919 [PubMed - in process]

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