iron deficiency anemia / Helicobacter pylori infection



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<<snip>> eradication of the infection may improve blood
parameters <<snip>>

Hepatogastroenterology. 2004 Jan-Feb;51(55):313-5. Links

Improvement of complete blood count in patients with iron
deficiency anemia and Helicobacter pylori infection after
the eradication of Helicobacter pylori.

Hacihanefioglu A, Edebali F, Celebi A, Karakaya T, Senturk
O, Hulagu S.

Department of Hematology, University of Kocaeli Medical
School, Sopali, Kocaeli, Turkey.

BACKGROUND/AIMS: Recent reports support the possible
association between Hp infection and iron deficiency anemia.
In the present study, the effects of the eradication therapy
on iron deficiency anemia were investigated. METHODOLOGY:
Fourteen women with iron deficiency anemia were enrolled
(mean age: 36.4 years; range: 20-52 years old). None of the
patients received iron supplementation. Several examinations
including upper and lower gastrointestinal endoscopy were
performed to reveal any gastrointestinal bleeding sites in
all patients. Gastric biopsies during endoscopy were taken
from the subjects except one whose serum anti-Hp IgG was
positive. After diagnosing the Hp infection by means of
microbiology, histology and Gram stain, a combination
therapy consisting of lansoprosol, clarithromycin and
amoxicillin was administered to each patient. Hematologic
examinations and the body iron status were evaluated
periodically, following the eradication therapy. RESULTS:
Endoscopic findings were as follows: Seven patients with
antral gastritis, two patients with pangastritis, whereas
five patients were found to be endoscopically normal. None
of the subjects were found to have gastrointestinal bleeding
of any type. Serum hemoglobin, iron and transferrin
saturations of the patients were found to be increased at
20-24 weeks of follow-up after the eradication therapy.
Serum ferritin levels were not found to be increased.
CONCLUSIONS: Hp infection may be involved in cases of iron
deficiency anemia of unknown origin, and the eradication of
the infection may improve blood parameters other than serum
ferritin levels.

PMID: 15011892 [PubMed - in process]

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