iron deficiency anemia / Helicobacter pylori infection

Discussion in 'Health and medical' started by Doe, Mar 12, 2004.

  1. Doe

    Doe Guest

    <<snip>> eradication of the infection may improve blood
    parameters <<snip>>

    Hepatogastroenterology. 2004 Jan-Feb;51(55):313-5. Links

    Improvement of complete blood count in patients with iron
    deficiency anemia and Helicobacter pylori infection after
    the eradication of Helicobacter pylori.

    Hacihanefioglu A, Edebali F, Celebi A, Karakaya T, Senturk
    O, Hulagu S.

    Department of Hematology, University of Kocaeli Medical
    School, Sopali, Kocaeli, Turkey.

    BACKGROUND/AIMS: Recent reports support the possible
    association between Hp infection and iron deficiency anemia.
    In the present study, the effects of the eradication therapy
    on iron deficiency anemia were investigated. METHODOLOGY:
    Fourteen women with iron deficiency anemia were enrolled
    (mean age: 36.4 years; range: 20-52 years old). None of the
    patients received iron supplementation. Several examinations
    including upper and lower gastrointestinal endoscopy were
    performed to reveal any gastrointestinal bleeding sites in
    all patients. Gastric biopsies during endoscopy were taken
    from the subjects except one whose serum anti-Hp IgG was
    positive. After diagnosing the Hp infection by means of
    microbiology, histology and Gram stain, a combination
    therapy consisting of lansoprosol, clarithromycin and
    amoxicillin was administered to each patient. Hematologic
    examinations and the body iron status were evaluated
    periodically, following the eradication therapy. RESULTS:
    Endoscopic findings were as follows: Seven patients with
    antral gastritis, two patients with pangastritis, whereas
    five patients were found to be endoscopically normal. None
    of the subjects were found to have gastrointestinal bleeding
    of any type. Serum hemoglobin, iron and transferrin
    saturations of the patients were found to be increased at
    20-24 weeks of follow-up after the eradication therapy.
    Serum ferritin levels were not found to be increased.
    CONCLUSIONS: Hp infection may be involved in cases of iron
    deficiency anemia of unknown origin, and the eradication of
    the infection may improve blood parameters other than serum
    ferritin levels.

    PMID: 15011892 [PubMed - in process]


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