Iron in neurodegenerative diseases



I

[email protected]

Guest
<<snip>>
a combination of iron chelation and antioxidant therapy might be a
significant approach to neuroprotection neurodegenerative diseases.
<<snip>>

J Mol Neurosci. 2004;24(3):401-16. Links


Iron and alpha-Synuclein in the Substantia Nigra of MPTP-Treated Mice:
Effect of Neuroprotective Drugs R-Apomorphine and Green Tea Polyphenol
(-)-Epigallocatechin-3-Gallate.

Mandel S, Maor G, Youdim MB.

Eve Topf and USA National Parkinson Foundation Centers of Excellence
for Neurodegenerative Diseases Research and Department of Pharmacology
and Rappaport Family Research Institute, Technion-Faculty of Medicine,
Haifa, 31096, Israel.

One of the prominent pathological features of Parkinson's disease (PD)
is the abnormal accumulation of iron in the substantia nigra pars
compacta (SNpc), in the reactive microglia, and in association with
neuromelanin, within the melanin-containing dopamine (DA) neurons. Lewy
body, the morphological hallmark of PD, is composed of lipids,
redox-active iron, and aggregated alpha-synuclein, concentrating in its
peripheral halo and ubiquitinated, hyperphosphorylated, neurofilament
proteins. The capacity of free iron to enhance and promote the
generation of toxic reactive oxygen radicals has been discussed
numerous times. Recent observations, that iron induces aggregation of
inert alpha-synuclein to toxic aggregates, have reinforced the critical
role of iron in oxidative stress-induced pathogenesis of DA neuron
degeneration and protein degradation via ubiquitination.
N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- and
6-hydroxydopamine-induced neurodegeneration in rodents and nonhuman
primates is associated with increased presence of iron and
alpha-synuclein in the SNpc. The accumulation of iron in MPTP-induced
neurodegeneration has been linked to nitric oxide-dependent mechanism,
resulting in degradation of prominent iron regulatory proteins by
ubiquitination. Radical scavengers such as R-apomorphine and green tea
catechin polyphenol (-)-epigallocatechin-3-gallate, as well as the
recently developed brain-permeable VK-28 series derivative iron
chelators, which are neuroprotective against these neurotoxins in mice
and rats, prevent the accumulation of iron and alpha-synuclein in SNpc.
This study supports the notion that a combination of iron chelation and
antioxidant therapy, as emphasized on several occasions, might be a
significant approach to neuroprotection in PD and other
neurodegenerative diseases.

PMID: 15655262 [PubMed - in process]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
On 19 Jan 2005 03:10:31 -0800, [email protected] wrote in
alt.support.mult-sclerosis:

>cYou are seeing this message because Tom Hennessy
aka [email protected] has posted a message in
alt.support.mult-sclerosis. If you are new to this
group then please understand that he appears to get
his thrills from the misfortunes of other people,
evidenced by his comments to the victims of forest
fires, the passing of members of this newsgroup and
his presence on all support newsgroups.

In keeping with his personality, Tommy believes
discussions in these groups are conducted by
using off-colour language and name calling
that would make a rattlesnake spew. This personality
trait is shown here:

http://makeashorterlink.com/?C3D412B0A

He seems to believe that whoever swears loudest and
longest is the winner.

In his mind, Hennessy believes he is a great
researcher who has won a Nobel Prize. In fact, he
merely copies medical material from the web and
pastes it to usenet, proudly calling this his research.

There was a time when people like Tommy were
institutionalized, now they are allowed to run for
public office and post to usenet. He is a fine
example why a mental health unit should not
obtain an internet account.

Previous addresses include [email protected],
[email protected], [email protected].

---
**** happens. You wish it happened every day if you have multiple sclerosis.
 
In article <[email protected]>,
"[email protected]" <[email protected]> wrote:

> You got something to say .. ?

Yes. You certainly haven't -- nothing of value anyway.

I've read nearly every one of your "scientific literature" citations. So
far, not one has been much more than obvious "publish or perish"
minutiae, of little applicability to MS or much else. That was just a
tiresome exercise I've recently ceased because of its futility.

Even I have better ways to waste my time.

Would it hurt you to equally readily cite the plentiful rebuttals to
your cites so readers could get a fuller understanding of their real
value?

I do admire your tenacity, however, when I'm not wondering at your lack
of skepticism.

>
> Who loves ya.

Well, I suppose I must, but only because Jesus so commands me. Hate the
sin, but love the sinner and all that.

> Tom
>
> Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
> Man Is A Herbivore!
> http://pages.ivillage.com/ironjustice/manisaherbivore
> DEAD PEOPLE WALKING
> http://pages.ivillage.com/ironjustice/deadpeoplewalking

Read all that stuff too; significantly less valuable than comic books:
At least they have some small entertainment value.

Good Lord, man, have you no discrimination at all?
 
On 19 Jan 2005 10:44:45 -0800, "[email protected]"
<[email protected]> wrote in alt.support.mult-sclerosis:

>You got something to say .. ?

You nincompoop, you have said nothing, not one word in that first
post is yours, is it?. You proudly copy and paste across four
newsgroups that which you believe is your brilliant research and
then you cry out hoping someone will say something favourable
about your spoor. Are you once again going to tell me that you
have won a Nobel Prize?
---
**** happens. You wish it happened every day if you have multiple sclerosis.
 
Yes .. you are correct ..

Quite surprising .. really ..

The article / scientific study is DIRECTLY out of Medline .. placed in
the appropriate groups .. pertaining to neurodegenerative diseases ..

Iron is mentioned ..

The TARGETING of .. iron .. is mentioned .. and antioxidants are
mentioned as a possible treatment to offset the oxidation .. KNOWN ..
oxidative .. stress ..

Now .. you have a problem with the post ..

Do ya .. stupid fat lying bald guy .. ?

I think you do ..

Heh .. heh ..

WHAT .. a freaking .. loser .. you really are ..

You know .. that .. ?

Heh .. heh ..

Now screw off you freaking nutbar ..

Who loves ya.
Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
Very scholarly language, Tom. Wouldn't surprise me a bit to hear you've
earned a second Nobel Prize.

In <news:[email protected]>,
[email protected] said:

> Yes .. you are correct ..
>
> Quite surprising .. really ..
>
> The article / scientific study is DIRECTLY out of Medline .. placed in
> the appropriate groups .. pertaining to neurodegenerative diseases ..
>
> Iron is mentioned ..
>
> The TARGETING of .. iron .. is mentioned .. and antioxidants are
> mentioned as a possible treatment to offset the oxidation .. KNOWN ..
> oxidative .. stress ..
>
> Now .. you have a problem with the post ..
>
> Do ya .. stupid fat lying bald guy .. ?
>
> I think you do ..
>
> Heh .. heh ..
>
> WHAT .. a freaking .. loser .. you really are ..
>
> You know .. that .. ?
>
> Heh .. heh ..
>
> Now screw off you freaking nutbar ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
> Man Is A Herbivore!
> http://pages.ivillage.com/ironjustice/manisaherbivore
> DEAD PEOPLE WALKING
> http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
You know you REALLY didn't .. say .. a whole helluva .. lot ..

I take it you are somewhat .. unimpressed ..

Heh .. heh ..

That is very good ..

Quiz .. time ..

WHO .. is .. 'the wife of your youth' ..

You should know that .. IF .. you read everything like you say you have
...

Or else you are just another lying piece of **** ..

Who loves ya.
Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
On 19 Jan 2005 19:02:46 -0800, [email protected] wrote in
alt.support.mult-sclerosis:

>Or else you are just another lying piece of **** ..

Gee, Tom, that is mild for you. Cleaned up your foul mouth a bit, I see. And
what happened to the "doe" part of your address? Wanting some spam now, are you?
Hope you get lots. :)

Who doesn't love YOU.
---
Joan
 
On 19 Jan 2005 18:28:29 -0800, "[email protected]"
<[email protected]> wrote in alt.support.mult-sclerosis:

>Iron is mentioned ..
>
>The TARGETING of .. iron .. is mentioned .. and antioxidants are
>mentioned as a possible treatment to offset the oxidation .. KNOWN ..
>oxidative .. stress ..
>
>Now .. you have a problem with the post ..
>
>Do ya .. stupid fat lying bald guy .. ?
>
>I think you do ..
>
>Heh .. heh ..
>
>WHAT .. a freaking .. loser .. you really are ..
>
>You know .. that .. ?
>
>Heh .. heh ..
>
>Now screw off you freaking nutbar ..

Your English is quite poor. Are you from a loony bin in Calgary?

Are you trying to say something beyond baby talk? Nope, didn't
think so. You might try "Hooked on Phonics", they speak well of
it on television.

I have told you before+ that Medline accepts anything for
publication,+ which supports the "publish or perish" comment made
by someone else. Oh, yes, and that little work you happily
posted in the arthritis conference. Yes, you remember the one,
it had only the first names of the investigators. A fishing
expedition by students who reeled in the boy fool.
--
From: watchman ([email protected])
[Now [email protected]]
Newsgroups: alt.support.thyroid
Date: 2002-01-12 15:56:30 PST
"Look lady .. if you don't know what you are talking about 'medically' ..
then stay out of it .. The man has had three miscarriages/spontaneous
abortions."
 
On 19 Jan 2005 19:02:46 -0800, [email protected] wrote in
alt.support.mult-sclerosis:

>WHO .. is .. 'the wife of your youth' ..
>
>You should know that .. IF .. you read everything like you say you have

He said he used to read all of your nonsense or words to that
effect. I doubt that you wrote the Book of Proverbs.
---
**** happens. You wish it happened every day if you have multiple sclerosis.
 
In article <[email protected]>,
[email protected] wrote:

> You know you REALLY didn't .. say .. a whole helluva .. lot ..

Difficulty reading, Tom? You've answered far less than I said.

>
> I take it you are somewhat .. unimpressed ..

Not nearly; I am _very_ unimpressed so far.

>
> Heh .. heh ..
>
> That is very good ..
>
> Quiz .. time ..
>
> WHO .. is .. 'the wife of your youth' ..

Who are the ***** of Babylon, the Abomination of Desolation, the Accuser
of the Brethren? Of whom was it said (other than you, who demonstrate it
daily): "Thinking themselves wise, they became fools?"

You should know those IF you're so wise as you purport.

>
> You should know that .. IF .. you read everything like you say you have
> ..
>
> Or else you are just another lying piece of **** ..

Baseless (and weak) assertion yet again, accompanied by another false
dichotomy. Accusing a questioner of falsehood is not defense, merely
rudeness. But there _is_ intellectual feces to be found -- on your site
and in your "book."

I said I've read your site and cites and so I have.

You post _your_ cites without reference to rebuttals. You offer no
refutation to the copious rebuttals to your cites other than to scream
like an aggrieved toddler: "Yes it is! You're a liar! Everybody is
against me!."

Well, I suppose you couldn't be expected to act differently from any
other purveyor of junk science.

First, last, and only hint: Rudely and repeatedly shouting your claims
does not constitute proof, or even defense.

Well, one should treat a toddler in a tantrum as it deserves.

Everybody is against you. Nobody likes you, everybody hates you. Please
go eat some worms. Nice and greasy, slide down easy. Nice and juicy
worms. Better not maybe: they might have iron in them. They are meat
after all. Spinach, among other vegetables, may also contain iron
compounds. Probably should avoid that as well.

There ya go, Hennessy; all the support for paranoiac delusional ideation
you'll ever need -- if you need any.

The sad part of the whole issue is: You _could_ be correct. Iron
metabolism _could_ play some role in neurogenic disease. It is so far
from proven, however, that it remains questionable and might equally
well be illusory.

No one will ever know from your method of defending it. Your rudeness
and emotionalism weaken all your arguments.

>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
> Man Is A Herbivore!
> http://pages.ivillage.com/ironjustice/manisaherbivore
> DEAD PEOPLE WALKING
> http://pages.ivillage.com/ironjustice/deadpeoplewalking

Prototypical troll; snips everything, answers nothing, full of sound and
fury, signifying only that.

Long past time: <plink>
 
In <news:[email protected]>,
[email protected] said:

> You seem to like to bring up the Nobel ..

Indeed, I do.

> Even though it was explained .. specifically ..

Your "explanation" was precisely as follows:

> You just .. 'don't get it' .. do ya ..
> My credentials are . . every medical article I post ..
> And if THAT doesn't make me a NOBEL PRIZE WINNER ..
> I don't know what would ..

See... the trouble here is that you state clearly that your actual
contribution amounts to nothing more than posting accounts of other people's
research and results.

Medline and other services already did that part before you... so I think
they're a long way ahead of you in the line-up for any Nobel that might
(around the time Hell freezes over, if I might hazard a guess,) be awarded
for "compiling and re-publishing the bare-bones abstracts of other people's
work".

And of course, there are also all sorts of replies and perfectly accurate
refutations of your assertion above, and you know perfectly well how to find
them all, so I won't copy them here.

The foremost among these is simply this: no one is, ever has been or ever
*will* be eligible for a Nobel in recognition solely of tireless, obsessive
and deluded effort in finding and copying other people's reports... in *any*
field of study.

Do .. you .. 'get it'?

I'm pretty sure you don't. You're *far* too important to allow the rules
that govern any field of research to be used to hold you accountable for
your ideas, pronouncements, or actions.
-- Michael
"It's just some kind of invasion or something.
But I agree...since Congress didn't call it a
war, I won't either."
- Angela Bassett-Hound
 
Regarding nobel and iron "research":

"The foremost among these is simply this: no one is, ever has been or ever
*will* be eligible for a Nobel in recognition solely of tireless,
obsessive
and deluded effort in finding and copying other people's reports... in
*any*
field of study."

Important also is that he doesn't typically understand most of the content
of what is posted nor the comments which often debunck the iron thesis.
It only reflects that one or more of the contents of a list, as described
on his pages, of words gets a hit in a search enjine. Then it is posted
only if he thinks it reflects well on the iron thesis, often a matter of
guessing and often wrong. Several of his postings in fact present all the
information required to over turn the iron thesis in detail because he
doesn't understand what it really says.
 
You've been TOLD .. "I never claimed a Nobel .. I won't attempt to
claim a Nobel .. " .. but .. since this is a medical subject .. IRON
BEING TARGETED IN NEURODEGENERATIVE DISORDERS .. and since you actually
KNOW fkall .. ABOUT .. science .. IE: radiation is NOT .. oxidation /
free radicals .. evidence based .. so you attempt and continue to ..
ridicule the .. poster OF the medical study ..

That is what I said .. and that is what I stick to ..

YOU are a fkg .. loser .. always WILL be a fkg .. loser and you will be
LONG FKG DEAD before .. I .. stop posting medical studies .. pertinent
/ relevant .. medical studies TO the appropriate groups .. WHENEVER I
FKG FEEL LIKE IT ..

You fkg .. dig .. ?

Or is that to hard for a twisted fk like you to understand .. eh ..
lefty ..

go eat some MORE raw fkg meat .. ya fkg .. freak ..

And STAY THE FK AWAY .. FROM .. me .. you twisted .. fk ..

Because talking to you is about as fkg creepy as talking to your ****
pushing pal ..

Dig .. ?
Underfkgstand ..?

Comfkgprendez .. ?

Who loves ya.
Tom


Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
 
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