Iron induced increase in adjuvant arthritis synovitis

Discussion in 'Food and nutrition' started by aolcom, Jul 18, 2005.

  1. aolcom

    aolcom Guest

    What .. part .. OF .. "giving iron supplements to a mammal WITH ..
    arthritis .. is a BAD .. thing .." .. don't you .. understand .. ?

    Heh .. heh ..

    Seems if you give iron supplements to animals .. OR .. children with
    arthritis .. it .. HURTS .. them ..

    But .. it seems .. the FACT .. it HURTS .. animals AND / or children ..
    makes NO .. nevermind to .. YOU ..

    I am just happy that .. you don't realize .. that when it hurts animals
    and children .. it very likely ALSO hurts .. you ..

    That means since you didn't ."go to the wall for the kids .. " .. when
    I first posted the supplements hurting KIDS .. study .. means by NOT ..
    advocating FOR .. the .. kids .. you .. effectively cut your .. OWN ..
    throat ..

    Heh .. heh ..

    Looks .. good .. on .. ya ..


    EXPERIMENTAL BIOLOGY UPDATE: Arthritic kids' iron supplements may
    hasten joint deterioration
    By Diana Swift
    WWASHINGTON, D.C. - The iron supplements that many arthritic children
    take to combat concomitant anemia may be hastening the deterioration of
    their joints, Houston researchers say.
    Led by biologist Roman Shypailo of the Children's Nutrition Research
    Centre at Baylor College of Medicine, a Texas team looked at eight
    children being treated for juvenile rheumatoid arthritis. The patients,
    aged five to 15 years, received an intravenous radioactive tracer dose
    of iron (0.03 microsievert). Iron activity in affected joints was
    monitored on a position/energy-sensitive gamma counter, while a second
    machine monitored whole-body iron retention. Iron deposition was
    measured two hours post-infusion and again at days seven, 14, 28 and
    56.
    Anemic
    "We found that iron excessively accumulates in arthritic joints and
    probably contributes to the chronic damage," said Shypailo. "That puts
    you between a rock and a hard place because many of these arthritic
    kids are anemic and need iron supplements, which may worsen the
    disease."
    The study found a high level of agreement between the joint data and
    the whole-body data, with a greater than 90% retention rate of the
    infused iron both in joints and systemically. Furthermore, six of eight
    patients showed increased uptake at the affected joints: 165% over the
    first 30 days compared with initial uptake at two hours.
    The next step, he says, is to see if there is excessive deposition of
    dietary iron in arthritic joints.


    IRON DEPOSITION IN THE JOINTS OF CHILDREN WITH JUVENILE RHEUMATOID
    ARTHRITIS

    Author(s):
    SHYPAILO ROMAN J
    ELLIS KENNETH J
    PEREZ MARIA
    ABRAMS STEVEN A

    Interpretive Summary:
    We wanted to develop an accurate and noninvasive way of
    determining the amount of iron deposited in the joints of
    patients with juvenile rheumatoid arthritis. Children with JRA
    often develop excess iron in their joints, so doctors need a
    way of monitoring the iron level, particularly when prescribing
    iron supplements for the common problem of anemia. However, the
    only method currently available is to take a biopsy. We adapted
    a machine called a gamma counter to measure the iron in eight
    patients' joints after giving them an iron isotope by vein.
    Then we compared the results with the total amount of iron in
    their bodies, measured by a whole-body counter. We found that
    we had developed an accurate new way of measuring iron in these
    patients' joints. We also found that six of the eight subjects
    had excess uptake of the iron isotope in their joints. That
    provided a signal that a preponderance of JRA patients are
    prone to have this problem, and clinicians should take special
    care to monitor them for it. Moreover, this is the first time a
    noninvasive way of performing this measurement has been
    available.

    Keywords:
    energy reproduction growth body composition women infants
    children water potassium bioelectrical impedance conductance
    bromide space lactating iron adipose tissue lipid motabolism
    beta-adrenergic receptor cell culture neutron activation
    nitrogen carbon calcium sodium chlorine phosphorus hormonal
    changes differentiation adipocyte hnrim021125

    Contact:
    USDA/ARS CHILDREN'S NUTR
    1100 BATES ST.
    HOUSTON
    TX 77030
    FAX: (713)798-7130
    Email: [email protected]

    Approved Date: 1999-01-07
    ______________________________________________________________________


    TEKTRAN
    United States Department of Agriculture
    Agricultural Research Service

    Updated: 1999-01-16



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    Tom

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