Iron induced increase in adjuvant arthritis synovitis



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What .. part .. OF .. "giving iron supplements to a mammal WITH ..
arthritis .. is a BAD .. thing .." .. don't you .. understand .. ?

Heh .. heh ..

Seems if you give iron supplements to animals .. OR .. children with
arthritis .. it .. HURTS .. them ..

But .. it seems .. the FACT .. it HURTS .. animals AND / or children ..
makes NO .. nevermind to .. YOU ..

I am just happy that .. you don't realize .. that when it hurts animals
and children .. it very likely ALSO hurts .. you ..

That means since you didn't ."go to the wall for the kids .. " .. when
I first posted the supplements hurting KIDS .. study .. means by NOT ..
advocating FOR .. the .. kids .. you .. effectively cut your .. OWN ..
throat ..

Heh .. heh ..

Looks .. good .. on .. ya ..


EXPERIMENTAL BIOLOGY UPDATE: Arthritic kids' iron supplements may
hasten joint deterioration
By Diana Swift
WWASHINGTON, D.C. - The iron supplements that many arthritic children
take to combat concomitant anemia may be hastening the deterioration of
their joints, Houston researchers say.
Led by biologist Roman Shypailo of the Children's Nutrition Research
Centre at Baylor College of Medicine, a Texas team looked at eight
children being treated for juvenile rheumatoid arthritis. The patients,
aged five to 15 years, received an intravenous radioactive tracer dose
of iron (0.03 microsievert). Iron activity in affected joints was
monitored on a position/energy-sensitive gamma counter, while a second
machine monitored whole-body iron retention. Iron deposition was
measured two hours post-infusion and again at days seven, 14, 28 and
56.
Anemic
"We found that iron excessively accumulates in arthritic joints and
probably contributes to the chronic damage," said Shypailo. "That puts
you between a rock and a hard place because many of these arthritic
kids are anemic and need iron supplements, which may worsen the
disease."
The study found a high level of agreement between the joint data and
the whole-body data, with a greater than 90% retention rate of the
infused iron both in joints and systemically. Furthermore, six of eight
patients showed increased uptake at the affected joints: 165% over the
first 30 days compared with initial uptake at two hours.
The next step, he says, is to see if there is excessive deposition of
dietary iron in arthritic joints.


IRON DEPOSITION IN THE JOINTS OF CHILDREN WITH JUVENILE RHEUMATOID
ARTHRITIS

Author(s):
SHYPAILO ROMAN J
ELLIS KENNETH J
PEREZ MARIA
ABRAMS STEVEN A

Interpretive Summary:
We wanted to develop an accurate and noninvasive way of
determining the amount of iron deposited in the joints of
patients with juvenile rheumatoid arthritis. Children with JRA
often develop excess iron in their joints, so doctors need a
way of monitoring the iron level, particularly when prescribing
iron supplements for the common problem of anemia. However, the
only method currently available is to take a biopsy. We adapted
a machine called a gamma counter to measure the iron in eight
patients' joints after giving them an iron isotope by vein.
Then we compared the results with the total amount of iron in
their bodies, measured by a whole-body counter. We found that
we had developed an accurate new way of measuring iron in these
patients' joints. We also found that six of the eight subjects
had excess uptake of the iron isotope in their joints. That
provided a signal that a preponderance of JRA patients are
prone to have this problem, and clinicians should take special
care to monitor them for it. Moreover, this is the first time a
noninvasive way of performing this measurement has been
available.

Keywords:
energy reproduction growth body composition women infants
children water potassium bioelectrical impedance conductance
bromide space lactating iron adipose tissue lipid motabolism
beta-adrenergic receptor cell culture neutron activation
nitrogen carbon calcium sodium chlorine phosphorus hormonal
changes differentiation adipocyte hnrim021125

Contact:
USDA/ARS CHILDREN'S NUTR
1100 BATES ST.
HOUSTON
TX 77030
FAX: (713)798-7130
Email: [email protected]

Approved Date: 1999-01-07
______________________________________________________________________


TEKTRAN
United States Department of Agriculture
Agricultural Research Service

Updated: 1999-01-16



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Tom

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