General fitness, health and nutrition · Public discussion

Iron Overload Predicts Infectious Disease

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General fitness, health and nutrition
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2 July 2007
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2 July 2007
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  1. Anyone in the .. sciences .. care to venture a .. "notion" .. why this
    would be .. so .. ?

    Heh .. heh ..

    Int J Infect Dis. 2007 Jun 26; [Epub ahead of print]Links
    Association of hemochromatosis with infectious diseases: expanding
    spectrum.Khan FA, Fisher MA, Khakoo RA.
    Department of Medicine, Section of Infectious Diseases, Ohio Valley
    Medical Center, 2000 Eoff Street, Wheeling, WV 26003, USA; Section of
    Infectious Diseases, West Virginia University Hospitals, Morgantown,
    WV 26506, USA.

    Withholding iron from potential pathogens is a host defense strategy.
    There is evidence that iron overload per se compromises the ability of
    phagocytes to kill microorganisms. Several hypotheses exist to explain
    the association of hemochromatosis with infection. A combination of
    mechanisms likely contributes to the increase in susceptibility to
    infection in these patients. A review of the current literature
    delineating various pathogens to which patients with hemochromatosis
    are potentially susceptible, and recent advances in the understanding
    of the association of hemochromatosis with infection, are discussed.

    PMID: 17600748 [PubMed - as supplied by publisher]

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