Iron supplementation worsens colitis

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Effects of iron manipulation on trace elements level in a model of
colitis in rats.
Barollo M, D'Inca R, Scarpa M, Medici V, Cardin R, Bortolami M, Ruffolo
C, Angriman I, Sturniolo GC
World J Gastroenterol. 2005 Jul 28; 11(28): 4396-9

AIM: Trace elements (TE) metabolism is altered in inflammatory bowel
diseases. TE (zinc and copper) are constituents of antioxidant enzymes.
Iron is involved in the pathogenesis of chronic inflammation. The aim
was to evaluate zinc and copper status and the effects of iron
manipulation in experimental colitis. METHODS: Twenty-four male
Sprague-Dawley rats were divided into four groups: standard diet,
iron-deprived diet, iron-supplemented diet, and sham-treated controls.
Macroscopic damage was scored. DNA adducts were measured in the colon.
Liver and colonic concentration of TE were measured. RESULTS:
Macroscopic damage was reduced in iron-deprived groups and increased in
iron-supplemented rats. Damage to the DNA was reduced in iron-deprived
groups and increased in iron-supplemented groups. Liver and colonic
iron concentrations were reduced in iron-deprived and increased in
iron-supplemented rats. Liver zinc concentration was reduced after
supplementation whereas colonic levels were similar in controls and
treated rats. Liver copper concentration was reduced in all the colitic
groups except in the iron-supplemented group whereas colonic
concentration was increased in iron-deprived rats. CONCLUSION: Iron
deprivation diminishes the severity of DNBS colitis while
supplementation worsens colitis. Zinc and copper status are modified by
iron manipulation.

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Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

I suppose one would have to .. NOW .. figure out .. WHAT .. actually ..
CONSTITUTES .. iron 'supplementation' ..?

Would fortified / iron enriched pasta BE .. considered .. iron
supplementation .. ?
Would your iron fortified cereal BE .. iron supplementation .. ?
Would your piece of iron fortified .. toast .. BE .. iron
supplementation .. ?

Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking

http://www.smartnutritionguide.com/white%20bread.htm

Some years a go, one of my students conducted a test, feeding mice
fortified breakfast cereals (enriched with a dozen or so vitamins). The
control mice ate whole grains.

The objective of the experiment was to feed pregnant mice the enriched
breakfast cereal and study the offspring. The idea was to to see if
what, if any, effects mom's diet had on the next generation. A week or
so after the student started the experiment, I was in my office when he
came in looking out of sorts. "What’s the problem?" I asked.

"My experiment is a failure."

The worried look came from the fact he believed he wouldn’t be able to
write a term paper based on the experiment. "So what’s gone wrong," I
said.

"The control mice did fine. But the pregnant females are dead."

Yes, the females never gave birth. They died within a week of starting
to eat the enriched breakfast cereal.

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Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking