K
Kyle Legate
Guest
Lots of caffeine (watch those pound bags of coffee in your suitcase), Frigo accused of possessing
testosterone and GH (but he only had it for
psychological reasons--that is, if it isn't just water), some corticosteroids for those nagging
saddle sores, but there are a couple of substances I consider a surprise:
Mannitol--can be used as a diruretic, possibly for rapid elimination of doping products, but no
other doping products found aside from the mannitol. Coupled with the normal racing-induced
dehydration, this could be quite dangerous.
ACTH--a pituitary hormone, stimulates the release of cortisol from the adrenal glands. Naturally
released by stress (like the Giro doesn't provide enough stress), its direct administration
overrides the usual negative feedback mechanism provided by cortisol to the hypothalamus. What a
stupid thing to do. Release of cortisol favours fatty acid metabolism over glucose metabolism, which
may provide benefit, but it also stimulates the breakdown of muscle into fatty acids, to be made
into glucose by the liver. Both accused holders of ACTH were also found with insulin, possibly in an
attempt to minimize muscle breakdown.
testosterone and GH (but he only had it for
psychological reasons--that is, if it isn't just water), some corticosteroids for those nagging
saddle sores, but there are a couple of substances I consider a surprise:
Mannitol--can be used as a diruretic, possibly for rapid elimination of doping products, but no
other doping products found aside from the mannitol. Coupled with the normal racing-induced
dehydration, this could be quite dangerous.
ACTH--a pituitary hormone, stimulates the release of cortisol from the adrenal glands. Naturally
released by stress (like the Giro doesn't provide enough stress), its direct administration
overrides the usual negative feedback mechanism provided by cortisol to the hypothalamus. What a
stupid thing to do. Release of cortisol favours fatty acid metabolism over glucose metabolism, which
may provide benefit, but it also stimulates the breakdown of muscle into fatty acids, to be made
into glucose by the liver. Both accused holders of ACTH were also found with insulin, possibly in an
attempt to minimize muscle breakdown.