J Am Geriatr Soc. 2004 Jan;52(1):106-11: depression and breast cancer

Discussion in 'Health and medical' started by James Michael H, Mar 2, 2004.

  1. I sent the following response to J Am Geriatr Soc. 2004 Jan;52(1):106-11. I thought some here may be
    interested.

    It is my hypothesis (1985) that depression may result from low dehydroepiandrosterone (DHEA). This
    has since been supported. In 1994, I first suggested low DHEA may trigger oncogene activity and
    explained this in the context of breast cancer. Therefore, the findings of Goodwin, et al., (J Am
    Geriatr Soc. 2004 Jan;52(1):106-11) were not unexpected.

    I suggest low DHEA participated in both depression and the initiation of breast cancer in the
    subjects of the study. Depression manifests itself before the cancer. Low DHEA may explain the
    "decreased survival after a diagnosis of breast cancer." My principal hypothesis is that DHEA
    optimizes transcription and replication of DNA. Therefore, DHEA levels affect all tissues. Reduced
    DHEA, therefore, may also account for "studies of [connections between] depression and other acute
    illnesses such as hip fracture and myocardial infarction."

    James Michael Howard www.anthropogeny.com
     
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