Free Radic Res. 2007 Apr;41(4):498-506.A hypocaloric diet enriched in
legumes specifically mitigates lipid peroxidation in obese
subjects.Crujeiras AB, Parra D, Abete I, Martinez JA.
Department of Physiology and Nutrition, University of Navarra.
Pamplona. Spain.
Legume intake could specifically protect against lipid peroxidation in
addition to the effects associated to weight loss when included in
hypocaloric diets. Thus, 30 obese subjects (age: 36 +/- 8 years and
BMI: 32.0 +/- 5.3 kg/m(2)) were nutritionally treated by a 8-week
energy restriction ( - 30% energy expenditure) with a legume enriched
diet (4 days/week servings, [image omitted] ) or without legumes
(control diet (CD), [image omitted] ). Body weight, circulating
cholesterol, oxidized LDL (ox-LDL), malondialdehyde (MDA) and urinary
8-isoprostane F(2alpha) (8-iso-PGF(2alpha)) were measured at baseline
and at endpoint. After the nutritional intervention, all obese
subjects lost weight, specially those individuals who followed the
legumes-enriched diet as compared to the CD ( - 7.7 +/- 3 vs. - 5.3
+/- 2.7%; p = 0.023), which was accompanied by marked decreases in
total cholesterol levels (p < 0.001) and statistically significant
diet-related reductions on plasma ox-LDL, plasma MDA and urinary 8-iso-
PGF(2alpha) output. Therefore, a balanced diet with moderate caloric
restriction including 4 day/week legume servings empowered the
oxidative stress improvement related to weight loss through a
reduction in lipid peroxidation as compared to a control hypocaloric
diet.
PMID: 17454132 [PubMed - in process]
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