Lipitor Raising My Glucose - Study Supports?

The FDA and the AMA use their pharmaceutical powers to keep sick
people dependant on them.
Their moto : more sick people we get sicker the more richer we become.

"aint no money in cures" Sam Manning

Rick wrote in message
<[email hidden]>...

Quoted message said:

After two separate trials, it was clear that 10mg Lipitor
(atorvastatin) was having an adverse effect on my glucose
control, which is typically in the high normal/low impaired
range since I lost weight. Pravachol (pravastatin) doesn't
have such an effect on me, but it doesn't lower my
cholesterol anywhere near as well either. (I haven't had
any other significant side effects from either drug except
some very mild and short-lived aching in one thigh.)

I originally posted about this late last year, starting a
thread called "Lipitor Clearly Worsening Glucose Control".
(Web link via Google:

groups.google.comgroupsOpen ↗
+glucose+control+ group:misc.health.diabetes

Quoted message said:

)

Since starting that original thread, I found the following
rodent study abstract on Medline. Granted, it was a small
exploratory study on animals, but the results parallel mine
so very closely, namely:
(1) "Subjects" started with "borderline" glucose
intolerance, (2) Lipitor increased post-meal glucose
sometimes while Pravachol didn't,
(3) This effect took a few weeks to emerge, and (4)
(Presumably), neither statin affected fasting glucose.

I wish someone would do a really GOOD, human study on this,
but who would fund it? Maybe in pre-diabetic or (thus far)
mildly diabetic people, even a minor deterioration in
glucose tolerance from Lipitor could outweigh the drug's
protective benefits.

I've set off the key conclusions below with asterisks.

Rick

Way back when I was on D & E + Metformin + Rezulin, I
started Lipitor and my sugars jumped. Thus, my
metabolism agrees with your metabolism.

However, one problem with your desire for studies and risk
evaluations in this area is that adding insulin to your
regime totally cancels any bG rise from Lipitor, e.g.. when
I re-started Lipitor after going on insulin, there was no
noticeable effect on bG at all, and my lipids improved
dramatically..

We have T2 on insulin posting about their 5.2 HbA1c. Thus,
in the docs' eyes, the problem is "solved".

Regards
Old Al

"oldal4865" <[email hidden]> wrote in message news:<[email hidden]>...

Quoted message said:

Rick wrote in message
<[email hidden]>...

Quoted message said:

After two separate trials, it was clear that 10mg Lipitor
(atorvastatin) was having an adverse effect on my glucose
control, which is typically in the high normal/low
impaired range since I lost weight. Pravachol
(pravastatin) doesn't have such an effect on me, but it
doesn't lower my cholesterol anywhere near as well
either. (I haven't had any other significant side effects
from either drug except some very mild and short-lived
aching in one thigh.)

I originally posted about this late last year, starting a
thread called "Lipitor Clearly Worsening Glucose
Control". (Web link via Google:

groups.google.comgroupsOpen ↗
ng+glucose+control+ group:misc.health.diabetes

Quoted message said:

)

Since starting that original thread, I found the
following rodent study abstract on Medline. Granted, it
was a small exploratory study on animals, but the results
parallel mine so very closely, namely:
(1) "Subjects" started with "borderline" glucose
intolerance, (2) Lipitor increased post-meal glucose
sometimes while Pravachol didn't,
(3) This effect took a few weeks to emerge, and (4)
(Presumably), neither statin affected fasting
glucose.

I wish someone would do a really GOOD, human study on
this, but who would fund it? Maybe in pre-diabetic or
(thus far) mildly diabetic people, even a minor
deterioration in glucose tolerance from Lipitor could
outweigh the drug's protective benefits.

I've set off the key conclusions below with asterisks.

Rick

Way back when I was on D & E + Metformin + Rezulin, I
started Lipitor and my sugars jumped. Thus, my
metabolism agrees with your metabolism.

However, one problem with your desire for studies and risk
evaluations in this area is that adding insulin to your
regime totally cancels any bG rise from Lipitor, e.g..
when I re-started Lipitor after going on insulin, there
was no noticeable effect on bG at all, and my lipids
improved dramatically..

We have T2 on insulin posting about their 5.2 HbA1c. Thus,
in the docs' eyes, the problem is "solved".

Regards
Old Al

Interesting feedback.

I ordered a copy of the complete study, and the authors say
that they had also done some prior work which showed *no*
significant glucose increase from Lipitor, but theorized
that this might be because the first sudy used rats that had
a more progressed level of diabetes that "may (have been)
too severe to detect influence of a drug on the diabetic
state." Now, I *have* seen summaries of a few studies
(including human studies) that cite Lipitor's lack of
significant effect on glycemia in diabetics, but I doubt
that -- unlike the current rat study -- these observations
were based on subjects purposely chosen for having currently
mild diabetes. Thus the effect may not have been apparent.

As for your own case, given that you were taking three meds
at the time Lipitor raised your sugars, this suggests that
the a Lipitor sugar-raising effect might also appear in
some cases of somewhat-more-progressed diabetes (but still
not at the insulin stage). For you, did it also take about
two weeks to start seeing Lipitor's effect on glucose? And
did it show up mostly in post-meal readings rather than
fasting? Was your statment about doctor reactions meant to
imply that you told your doctor about the effect and he/she
dismissed it?

Thanks for the contribution.

Rick

Sam I heard something of this on another website. It is easy
to fix just change statins, I use Zocor with no problems.
Larry D NJ

Sam Manning said:

The FDA and the AMA use their pharmaceutical powers to
keep sick people dependant on them. Their moto : more sick
people we get sicker the more richer we become.

"aint no money in cures" Sam Manning