Lowered cholesterol & aggression

It seems to me I heard somewhere that Zee wrote in article
<[email hidden]>:

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STATINS AND NON-CARDIAC ENDPOINTS Authors:

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GOLOMB BA

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Author Address: [email hidden], UCSD SCHOOL OF MEDICINE,
9500 GILMAN DRIVE, 0995, LA JOLLA, CA 92093-0995

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Source: Crisp Data Base National Institutes of Health

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Abstract:

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DESCRIPTION (adapted from investigator's abstract): A
*relation of lowered cholesterol to increased aggressive
behaviors* (including suicide) and impaired cognition has
been variably demonstrated and remains to be established or
excluded with confidence. HMG-CoA reductase inhibitors
("statins"😉 are the most widely used agents and their
effects are of special interest. Purpose: To examine the
effect of statins on aggressive responding, cognition, and
serotonin in individuals with moderate LDL and no
identified cardiovascular disease
(CVD). Hypothesis: Statin therapy will increase aggressive
responding on the PSAP (Point Subtraction Aggression
paradigm, a standardized aggression measure that
correlates with both violent behavior and serotonin);
will reduce measures of cognition (including
psychomotor speed and attention); and will change
serotonin (gauged by whole blood serotonin), which may
be a mediator of effects on behavior and perhaps
cognition. Secondarily, it is hypothesized that
simvastatin (lipophilic) will exert more potent
effects on cognition (and perhaps aggression) than
pravastatin (hydrophilic); that serotonin (5HT)
changes will related to changes in aggressive
responding and perhaps cognition; and that a
"susceptible subset" may be defined by baseline
characteristics including biochemistry, mood,
personality, and extremes of cardiovascular
reactivity.

Were you going to comment on this prospectus for the study?
I see the hypotheses to be tested, both relating to a
possible connection between statins and behavior including
aggressiveness, but if the study has been done what were the
results? Is there a URL?
--
Don [email hidden]

Don Kirkman <[email hidden]> wrote in message news:<[email hidden]>...

Quoted message said:

It seems to me I heard somewhere that Zee wrote in article
<[email hidden]>:

Quoted message said:

STATINS AND NON-CARDIAC ENDPOINTS Authors:

Quoted message said:

GOLOMB BA

Quoted message said:

Author Address: [email hidden], UCSD SCHOOL OF
MEDICINE, 9500 GILMAN DRIVE, 0995, LA JOLLA, CA 92093-
0995

Quoted message said:

Source: Crisp Data Base National Institutes of Health

Quoted message said:

Abstract:

Quoted message said:

DESCRIPTION (adapted from investigator's abstract): A
*relation of lowered cholesterol to increased aggressive
behaviors* (including suicide) and impaired cognition has
been variably demonstrated and remains to be established
or excluded with confidence. HMG-CoA reductase inhibitors
("statins"😉 are the most widely used agents and their
effects are of special interest. Purpose: To examine the
effect of statins on aggressive responding, cognition,
and serotonin in individuals with moderate LDL and no
identified cardiovascular disease
(CVD). Hypothesis: Statin therapy will increase
aggressive responding on the PSAP (Point Subtraction
Aggression paradigm, a standardized aggression
measure that correlates with both violent behavior
and serotonin); will reduce measures of cognition
(including psychomotor speed and attention); and
will change serotonin (gauged by whole blood
serotonin), which may be a mediator of effects on
behavior and perhaps cognition. Secondarily, it is
hypothesized that simvastatin (lipophilic) will
exert more potent effects on cognition (and perhaps
aggression) than pravastatin (hydrophilic); that
serotonin (5HT) changes will related to changes in
aggressive responding and perhaps cognition; and
that a "susceptible subset" may be defined by
baseline characteristics including biochemistry,
mood, personality, and extremes of cardiovascular
reactivity.

Were you going to comment on this prospectus for the
study?

No. I merely posted it because I thought perhaps many had
not seen what her study will actually "study". As I
understand these things (please correct me if you have
better knowledge) this is all she can study: what has been
set out and funded. When I last spoke with her, she said
they are trying to get monies for some other aspects they
wish to investigate.

I see the

Quoted message said:

hypotheses to be tested, both relating to a possible
connection between statins and behavior including
aggressiveness, but if the study has been done what were
the results? Is there a URL?

The study is not finished. This is the only url that I have.

medicine.ucsd.eduindex.htmOpen ↗

B'adant

It seems to me I heard somewhere that Zee wrote in article
<[email hidden]>:

Quoted message said:

Don Kirkman <[email hidden]> wrote in message
news:<[email hidden]>...

Quoted message said:

It seems to me I heard somewhere that Zee wrote in
article
<[email hidden]>:

Quoted message said:

Quoted message said:

Quoted message said:

STATINS AND NON-CARDIAC ENDPOINTS Authors:

Quoted message said:

Quoted message said:

Quoted message said:

GOLOMB BA

[...]

Quoted message said:

Quoted message said:

Were you going to comment on this prospectus for
the study?

Quoted message said:

No. I merely posted it because I thought perhaps many had
not seen what her study will actually "study". As I
understand these things (please correct me if you have
better knowledge) this is all she can study: what has been
set out and funded. When I last spoke with her, she said
they are trying to get monies for some other aspects they
wish to investigate.

[...]

Quoted message said:

The study is not finished. This is the only url that I
have.

Quoted message said:

medicine.ucsd.eduindex.htmOpen ↗

Okay, it's the one we've been talking about all the time
lately. I thought you were giving us something new.
--
Don [email hidden]